Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/9vs CaliforniaL  2-6 0-1
4/10vs CaliforniaW  10-2 1-1
4/11vs CaliforniaL  4-7 1-2
4/12vs CaliforniaL  6-8 1-3
4/14vs MinnesotaL  4-5 1-4
4/15vs MinnesotaW  6-5 2-4
4/17at OaklandL  1-16 2-5
4/18at OaklandL  0-8 2-6
4/19at OaklandW  3-2 3-6
4/19at OaklandL  1-6 3-7
4/20at CaliforniaL  1-6 3-8
4/21at CaliforniaW  3-0 4-8
4/22at CaliforniaL  3-7 4-9
4/24vs OaklandL  2-6 4-10
4/25vs OaklandL  4-7 4-11
4/26vs OaklandL  4-9 4-12
4/27at MinnesotaW  8-3
10
5-12
4/28at MinnesotaL  1-4 5-13
4/30vs DetroitL  0-2 5-14
5/1vs DetroitL  3-7 5-15
5/2vs DetroitW  3-1 6-15
5/3vs DetroitL  5-8 6-16
5/4vs MilwaukeeL  5-9 6-17
5/5vs MilwaukeeL  1-4 6-18
5/6vs MilwaukeeW  12-1 7-18
5/7vs MilwaukeeW  4-1 8-18
5/8vs NY YankeesW  3-2 9-18
5/9vs NY YankeesW  6-5 10-18
5/10vs NY YankeesL  2-5 10-19
5/12at DetroitL  2-6 10-20
5/13at DetroitL  0-1 10-21
5/16at NY YankeesL  5-7 10-22
5/17at NY YankeesW  1-0 11-22
5/18at BostonL  5-8 11-23
5/19at BostonL  0-4 11-24
5/20at ClevelandW  3-1 12-24
5/21at ClevelandW  6-3 13-24
5/22vs TexasL  2-6 13-25
5/23vs TexasL  4-6
12
13-26
5/24vs TexasL  3-5 13-27
5/25vs Kansas CityW  5-2 14-27
5/25vs Kansas CityW  7-1 15-27
5/26vs Kansas CityL  4-5 15-28
5/27vs Kansas CityL  5-8 15-29
5/29at TexasW  5-4
12
16-29
5/30at TexasL  0-6 16-30
5/31at TexasW  5-3 17-30
6/1at Kansas CityL  2-3 17-31
6/2at Kansas CityW  4-3 18-31
6/3at Kansas CityL  9-12 18-32
6/5vs ClevelandL  1-8 18-33
6/6vs ClevelandL  3-5 18-34
6/7vs ClevelandW  5-4
11
19-34
6/8vs BostonW  2-0 20-34
6/9vs BostonL  1-10 20-35
6/10vs BostonL  2-4 20-36
6/11vs BaltimoreW  8-2 21-36
8/10vs CaliforniaW  5-4 22-36
8/11vs CaliforniaW  4-1 23-36
8/12vs CaliforniaL  1-4
11
23-37
8/13at MinnesotaW  11-1 24-37
8/14at MinnesotaW  13-3 25-37
8/14at MinnesotaL  1-6 25-38
8/15at MinnesotaW  6-0 26-38
8/16at MinnesotaW  7-4 27-38
8/18vs ClevelandL  2-5 27-39
8/19vs ClevelandW  4-3
10
28-39
8/20vs ClevelandL  5-6
13
28-40
8/21vs BostonL  4-7 28-41
8/22vs BostonL  3-5 28-42
8/23vs BostonL  5-7 28-43
8/24vs BaltimoreL  8-12 28-44
8/25vs BaltimoreL  5-6
12
28-45
8/27at ClevelandL  2-12 28-46
8/28at ClevelandL  0-1 28-47
8/29at ClevelandL  3-7 28-48
8/30at ClevelandL  11-17 28-49
8/31at BaltimoreW  4-3 29-49
9/1at BaltimoreL  0-1 29-50
9/2at BaltimoreL  2-3
11
29-51
9/3at BostonW  8-7
20
30-51
9/4at BostonW  5-2 31-51
9/5at BostonL  5-12 31-52
9/6at BostonL  1-6 31-53
9/7at Chi. White SoxW  9-5 32-53
9/8at Chi. White SoxL  3-5 32-54
9/9at Chi. White SoxW  3-1 33-54
9/10at TorontoL  0-2 33-55
9/11at TorontoW  8-1 34-55
9/12at TorontoL  0-3 34-56
9/14vs Chi. White SoxL  2-5 34-57
9/15vs Chi. White SoxW  8-4 35-57
9/16vs Chi. White SoxL  1-3 35-58
9/18vs Kansas CityL  3-8 35-59
9/19vs Kansas CityW  4-1 36-59
9/20vs Kansas CityW  3-2 37-59
9/21at TexasL  1-4 37-60
9/22at TexasW  3-2 38-60
9/23at TexasW  2-1 39-60
9/24at TexasW  2-1
11
40-60
9/25at Kansas CityW  8-3 41-60
9/26at Kansas CityW  4-2 42-60
9/27at Kansas CityL  3-15 42-61
9/28vs TexasL  5-6 42-62
9/29vs TexasL  2-6 42-63
9/30vs TexasL  1-3 42-64
10/2vs TorontoW  8-3 43-64
10/3vs TorontoL  3-4 43-65
10/4vs TorontoW  2-0 44-65