Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/9vs San DiegoL  1-4
12
0-1
4/10vs San DiegoL  2-4 0-2
4/11vs San DiegoW  2-0 1-2
4/12vs San DiegoW  7-6
14
2-2
4/13vs LA DodgersL  3-4 2-3
4/14vs LA DodgersL  1-7 2-4
4/15vs LA DodgersL  2-4 2-5
4/17at AtlantaW  6-2 3-5
4/18at AtlantaW  4-1 4-5
4/19at AtlantaL  3-4 4-6
4/20at San DiegoW  9-0 5-6
4/21at San DiegoL  1-3 5-7
4/22at San DiegoL  0-4 5-8
4/23vs AtlantaL  3-7 5-9
4/24vs AtlantaL  1-7 5-10
4/25vs AtlantaL  0-4 5-11
4/26vs AtlantaW  8-5 6-11
4/26vs AtlantaW  3-1 7-11
4/27at LA DodgersL  0-5 7-12
4/28at LA DodgersW  6-1 8-12
4/29at LA DodgersW  3-2 9-12
5/2at PhiladelphiaW  6-2 10-12
5/2at PhiladelphiaL  1-3 10-13
5/3at PhiladelphiaL  5-7 10-14
5/4at PhiladelphiaL  4-6 10-15
5/5at NY MetsW  9-7 11-15
5/6at NY MetsW  6-4 12-15
5/7at NY MetsL  2-3 12-16
5/8at MontrealW  4-3 13-16
5/9at MontrealW  8-2 14-16
5/10at MontrealL  0-4 14-17
5/10at MontrealW  5-1 15-17
5/12vs PhiladelphiaW  4-0 16-17
5/13vs PhiladelphiaW  5-2 17-17
5/14vs PhiladelphiaL  1-3 17-18
5/15vs MontrealW  4-2 18-18
5/16vs MontrealL  0-5 18-19
5/17vs MontrealW  5-4
12
19-19
5/18vs NY MetsW  3-1 20-19
5/19vs NY MetsW  4-1 21-19
5/20vs NY MetsL  3-4
10
21-20
5/22at HoustonW  6-3
15
22-20
5/23at HoustonL  3-5 22-21
5/24at HoustonW  2-1 23-21
5/25at CincinnatiL  3-6 23-22
5/27at CincinnatiL  2-3 23-23
5/28at CincinnatiL  4-7 23-24
5/29vs HoustonW  3-1 24-24
5/30vs HoustonL  8-9
14
24-25
5/31vs HoustonW  6-1 25-25
6/1vs CincinnatiL  5-8 25-26
6/2vs CincinnatiW  15-7 26-26
6/3vs CincinnatiL  2-6 26-27
6/5at PittsburghW  5-3 27-27
6/6at PittsburghL  6-7 27-28
6/7at PittsburghL  2-3 27-29
6/9at Chi. CubsL  1-2 27-30
6/10at Chi. CubsL  4-7 27-31
6/11at Chi. CubsL  1-6 27-32
8/10vs HoustonL  5-6 27-33
8/11vs HoustonW  3-2 28-33
8/12vs HoustonL  4-5 28-34
8/14at CincinnatiL  6-7
10
28-35
8/14at CincinnatiW  4-0 29-35
8/15at CincinnatiW  5-2 30-35
8/16at CincinnatiL  1-2 30-36
8/17at PittsburghW  5-1
11
31-36
8/18at PittsburghW  4-2 32-36
8/19at PittsburghL  3-7 32-37
8/21at Chi. CubsW  4-3 33-37
8/22at Chi. CubsW  2-1 34-37
8/23at Chi. CubsL  5-6 34-38
8/24at StL CardinalsL  1-2
10
34-39
8/25at StL CardinalsW  4-2 35-39
8/26at StL CardinalsL  4-9 35-40
8/27vs PittsburghW  5-4
13
36-40
8/28vs PittsburghW  5-1 37-40
8/29vs PittsburghW  8-3 38-40
8/30vs PittsburghW  5-0 39-40
9/1vs StL CardinalsW  4-2 40-40
9/2vs StL CardinalsL  2-5 40-41
9/3vs Chi. CubsW  12-0 41-41
9/4vs Chi. CubsW  3-2
10
42-41
9/5vs Chi. CubsL  2-8 42-42
9/6vs Chi. CubsW  3-0 43-42
9/7at LA DodgersL  1-5 43-43
9/8at LA DodgersL  0-4 43-44
9/9at LA DodgersW  6-3
11
44-44
9/11at HoustonL  0-6 44-45
9/12at HoustonL  2-5 44-46
9/13at HoustonL  0-3 44-47
9/14vs AtlantaW  4-2 45-47
9/15vs AtlantaW  6-5 46-47
9/16vs CincinnatiW  12-7 47-47
9/17vs CincinnatiL  0-1
10
47-48
9/18vs HoustonW  5-2 48-48
9/19vs HoustonL  1-8 48-49
9/20vs HoustonL  3-7 48-50
9/22vs LA DodgersW  5-2 49-50
9/23vs LA DodgersW  8-4 50-50
9/24vs LA DodgersL  3-7 50-51
9/25at San DiegoW  3-0 51-51
9/26at San DiegoW  6-5 52-51
9/27at San DiegoW  7-3 53-51
9/28at CincinnatiW  4-0 54-51
9/29at CincinnatiL  3-4 54-52
9/30at AtlantaL  2-9 54-53
10/1at AtlantaW  6-2 55-53
10/3vs San DiegoL  3-4
13
55-54
10/3vs San DiegoL  2-7 55-55
10/4vs San DiegoW  4-3 56-55