Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/9vs OaklandL  1-5 0-1
4/10vs OaklandL  3-6 0-2
4/11vs OaklandL  0-3 0-3
4/12vs OaklandL  0-1 0-4
4/14at SeattleW  5-4 1-4
4/15at SeattleL  5-6 1-5
4/17at CaliforniaL  0-4 1-6
4/18at CaliforniaW  6-4 2-6
4/20at OaklandL  0-3 2-7
4/21at OaklandL  3-4
10
2-8
4/22at OaklandL  1-2 2-9
4/24vs CaliforniaW  7-5 3-9
4/25vs CaliforniaL  4-6 3-10
4/26vs CaliforniaL  1-7 3-11
4/26vs CaliforniaW  5-2 4-11
4/27vs SeattleL  3-8
10
4-12
4/28vs SeattleW  4-1 5-12
4/30at BostonW  8-4 6-12
5/1at BostonW  6-1 7-12
5/2at BostonW  11-2 8-12
5/3at BostonW  3-1 9-12
5/4at BaltimoreL  3-4
10
9-13
5/5at BaltimoreL  2-3 9-14
5/6at BaltimoreL  4-5 9-15
5/8vs ClevelandW  8-7 10-15
5/9vs ClevelandL  1-2
10
10-16
5/10vs ClevelandL  1-5 10-17
5/12vs BostonW  4-3
10
11-17
5/13vs BostonL  2-5 11-18
5/14vs BostonL  7-9
11
11-19
5/15vs BaltimoreL  4-9 11-20
5/16vs BaltimoreL  0-7 11-21
5/17vs BaltimoreL  3-6 11-22
5/19at MilwaukeeL  3-4 11-23
5/20at MilwaukeeL  1-6 11-24
5/21at MilwaukeeL  2-8 11-25
5/22at Kansas CityW  7-0 12-25
5/23at Kansas CityL  0-1
15
12-26
5/24at Kansas CityL  4-6 12-27
5/25at TexasL  3-4 12-28
5/26at TexasL  1-2 12-29
5/27at TexasW  2-1 13-29
5/28at TexasL  2-6 13-30
5/29vs Kansas CityL  1-3 13-31
5/30vs Kansas CityL  5-6 13-32
5/31vs Kansas CityW  5-4 14-32
6/2vs TexasL  3-5 14-33
6/3vs TexasL  3-6 14-34
6/4vs TexasW  7-3 15-34
6/5at DetroitL  0-2 15-35
6/6at DetroitL  1-5 15-36
6/7at DetroitL  0-3 15-37
6/8vs MilwaukeeW  1-0 16-37
6/9vs MilwaukeeW  3-1 17-37
6/10vs DetroitL  2-4 17-38
6/11vs DetroitL  2-7 17-39
8/10vs OaklandW  6-2 18-39
8/11vs OaklandL  5-6 18-40
8/12vs OaklandW  4-3 19-40
8/13vs SeattleL  1-11 19-41
8/14vs SeattleL  3-13 19-42
8/14vs SeattleW  6-1 20-42
8/15vs SeattleL  0-6 20-43
8/16vs SeattleL  4-7 20-44
8/17at DetroitL  2-12 20-45
8/18at DetroitL  0-3 20-46
8/19at DetroitL  0-4 20-47
8/21at MilwaukeeW  7-6 21-47
8/22at MilwaukeeL  3-4
10
21-48
8/23at MilwaukeeL  5-8 21-49
8/24at NY YankeesW  3-2
12
22-49
8/25at NY YankeesW  3-0 23-49
8/26at NY YankeesL  2-3 23-50
8/27vs DetroitW  4-3 24-50
8/28vs DetroitW  6-0 25-50
8/29vs DetroitW  7-1 26-50
8/30vs DetroitL  1-6 26-51
8/31vs NY YankeesL  0-7 26-52
9/1vs NY YankeesL  6-11 26-53
9/2vs NY YankeesW  4-3 27-53
9/3vs MilwaukeeL  3-4 27-54
9/4vs MilwaukeeL  5-16 27-55
9/5vs MilwaukeeL  3-5 27-56
9/6vs MilwaukeeL  7-8
10
27-57
9/7vs TorontoW  4-0 28-57
9/8vs TorontoW  1-0 29-57
9/9vs TorontoW  3-1 30-57
9/11vs Chi. White SoxW  4-3 31-57
9/12vs Chi. White SoxW  3-1 32-57
9/13vs Chi. White SoxW  7-6 33-57
9/14at TorontoW  6-3 34-57
9/15at TorontoL  2-4 34-58
9/16at TorontoW  5-2 35-58
9/18at TexasW  6-3 36-58
9/19at TexasL  0-6 36-59
9/20at TexasL  3-4 36-60
9/21at Kansas CityW  7-2 37-60
9/22at Kansas CityL  1-2 37-61
9/23at Kansas CityW  6-2 38-61
9/24at Kansas CityL  2-9 38-62
9/25vs TexasL  2-5 38-63
9/26vs TexasW  7-3 39-63
9/27vs TexasW  5-2 40-63
9/28vs Kansas CityL  1-6 40-64
9/29vs Kansas CityL  2-4 40-65
9/30vs Kansas CityL  2-5 40-66
10/2at Chi. White SoxW  3-2 41-66
10/3at Chi. White SoxL  4-5 41-67
10/4at Chi. White SoxL  12-13 41-68