The season was extended one week, each team playing 17 games with one bye-week across the 18-week schedule.

2021 Regular Season Results

Date    OpponentResultScoreRecord
9/12vs ChicagoW  34-14 1-0
9/19at IndianapolisW  27-24 2-0
9/26vs Tampa BayW  34-24 3-0
10/3vs ArizonaL  20-37 3-1
10/7at SeattleW  26-17 4-1
10/17at NY GiantsW  38-11 5-1
10/24vs DetroitW  28-19 6-1
10/31at HoustonW  38-22 7-1
11/7vs TennesseeL  16-28 7-2
11/15at San FranciscoL  10-31 7-3
11/28at Green BayL  28-36 7-4
12/5vs JacksonvilleW  37-7 8-4
12/13at ArizonaW  30-23 9-4
12/21vs SeattleW  20-10 10-4
12/26at MinnesotaW  30-23 11-4
1/2at BaltimoreW  20-19 12-4
1/9vs San FranciscoL  24-27
OT
12-5