The season was impacted by the ongoing COVID-19 pandemic; the most prominent changes were the cancellation of all preseason games and the postponement and/or rescheduling of multiple games due to positive COVID-19 tests among players and staff. Despite the changes, all 256 regular season games were played within the original 17-week span, with no cancellations.
2020 Regular Season Results | |||||||||||||||||||
| Date | Opponent | Result | Score | OT | Record | ||||||||||||||
| 9/13 | at Minnesota | W | 43-34 | 1-0 | |||||||||||||||
| 9/20 | vs Detroit | W | 42-21 | 2-0 | |||||||||||||||
| 9/27 | at New Orleans | W | 37-30 | 3-0 | |||||||||||||||
| 10/5 | vs Atlanta | W | 30-16 | 4-0 | |||||||||||||||
| 10/18 | at Tampa Bay | L | 10-38 | 4-1 | |||||||||||||||
| 10/25 | at Houston | W | 35-20 | 5-1 | |||||||||||||||
| 11/1 | vs Minnesota | L | 22-28 | 5-2 | |||||||||||||||
| 11/5 | at San Francisco | W | 34-17 | 6-2 | |||||||||||||||
| 11/15 | vs Jacksonville | W | 24-20 | 7-2 | |||||||||||||||
| 11/22 | at Indianapolis | L | 31-34 | 7-3 | |||||||||||||||
| 11/29 | vs Chicago | W | 41-25 | 8-3 | |||||||||||||||
| 12/6 | vs Philadelphia | W | 30-16 | 9-3 | |||||||||||||||
| 12/13 | at Detroit | W | 31-24 | 10-3 | |||||||||||||||
| 12/19 | vs Carolina | W | 24-16 | 11-3 | |||||||||||||||
| 12/27 | vs Tennessee | W | 40-14 | 12-3 | |||||||||||||||
| 1/3 | at Chicago | W | 35-16 | 13-3 | |||||||||||||||