Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/11vs MilwaukeeL  3-5 0-1
4/12vs MilwaukeeL  1-6 0-2
4/14at TexasW  7-1 1-2
4/15at TexasL  0-8 1-3
4/16at MilwaukeeW  1-0 2-3
4/18at MilwaukeeW  5-0 3-3
4/20at Kansas CityW  4-2 4-3
4/21at Kansas CityW  4-1 5-3
4/22at Kansas CityW  4-0 6-3
4/25vs TexasL  4-8 6-4
4/26vs TexasW  4-3 7-4
4/30vs Chi. White SoxW  3-2 8-4
5/1vs Chi. White SoxW  10-2 9-4
5/2vs Chi. White SoxW  3-1 10-4
5/3vs Chi. White SoxL  0-6 10-5
5/6at TorontoW  4-1 11-5
5/7at TorontoL  2-6 11-6
5/8at MinnesotaL  7-8 11-7
5/9at MinnesotaW  2-1
10
12-7
5/10at MinnesotaW  5-1 13-7
5/11at Chi. White SoxW  3-1 14-7
5/12at Chi. White SoxL  4-7 14-8
5/13at Chi. White SoxW  4-3
16
15-8
5/15vs TorontoW  3-0 16-8
5/16vs TorontoL  1-4 16-9
5/17vs TorontoW  1-0 17-9
5/17vs TorontoW  2-1
10
18-9
5/18vs CaliforniaL  2-7 18-10
5/19vs CaliforniaW  7-3 19-10
5/20vs SeattleL  1-3 19-11
5/21vs SeattleL  3-6 19-12
5/22at NY YankeesW  7-3 20-12
5/23at NY YankeesL  2-3 20-13
5/24at NY YankeesW  12-5 21-13
5/25at BostonL  7-8 21-14
5/26at BostonW  5-2 22-14
5/27at BostonL  5-10 22-15
5/29vs NY YankeesL  2-5 22-16
5/30vs NY YankeesL  0-1 22-17
5/31vs NY YankeesW  7-2 23-17
6/1vs NY YankeesL  3-5 23-18
6/2vs BostonL  0-4 23-19
6/3vs BostonW  4-1 24-19
6/4vs BostonL  5-6 24-20
6/5at SeattleW  8-1 25-20
6/6at SeattleW  5-3 26-20
6/7at SeattleL  4-5
11
26-21
6/8at CaliforniaL  2-10 26-22
6/9at CaliforniaL  2-4 26-23
6/10at CaliforniaL  3-4 26-24
8/10vs MilwaukeeL  2-5
13
26-25
8/11vs MilwaukeeL  1-6 26-26
8/11vs MilwaukeeL  5-6 26-27
8/12vs MilwaukeeW  9-4 27-27
8/13vs MilwaukeeL  5-8 27-28
8/14vs Kansas CityL  1-4 27-29
8/15vs Kansas CityL  3-5 27-30
8/16vs Kansas CityW  8-6 28-30
8/16vs Kansas CityL  2-6 28-31
8/18at SeattleW  5-2 29-31
8/19at SeattleL  3-4
10
29-32
8/20at SeattleW  6-5
13
30-32
8/21at CaliforniaL  2-12 30-33
8/22at CaliforniaL  2-3
10
30-34
8/23at CaliforniaW  6-3 31-34
8/24at OaklandL  4-16 31-35
8/25at OaklandW  2-0 32-35
8/27vs SeattleW  12-2 33-35
8/28vs SeattleW  1-0 34-35
8/29vs SeattleW  7-3 35-35
8/30vs SeattleW  17-11 36-35
8/31vs OaklandL  3-5 36-36
9/2vs OaklandW  10-4 37-36
9/2vs OaklandW  2-0 38-36
9/4vs CaliforniaL  1-3 38-37
9/5vs CaliforniaW  4-2 39-37
9/5vs CaliforniaW  4-2 40-37
9/6vs CaliforniaW  2-0 41-37
9/7at BaltimoreL  2-9 41-38
9/8at BaltimoreL  5-14 41-39
9/9at BaltimoreW  8-5 42-39
9/10at BaltimoreW  4-1 43-39
9/11at DetroitL  3-6 43-40
9/12at DetroitL  9-11
12
43-41
9/13at DetroitL  6-8 43-42
9/15vs BaltimoreL  6-7 43-43
9/17vs BaltimoreL  2-6 43-44
9/18vs DetroitW  8-4 44-44
9/19vs DetroitL  3-4 44-45
9/20vs DetroitL  1-5 44-46
9/21at NY YankeesW  5-0 45-46
9/22at NY YankeesW  6-4 46-46
9/23at NY YankeesL  1-6 46-47
9/24at BostonW  5-2 47-47
9/25at BostonL  4-5 47-48
9/26at BostonW  7-5 48-48
9/27at BostonW  8-7
11
49-48
9/28vs NY YankeesW  6-2 50-48
9/29vs NY YankeesW  3-2 51-48
10/2vs BostonW  11-4 52-48
10/3vs BostonL  0-4 52-49
10/4vs BostonL  2-6 52-50
10/5vs Kansas CityL  0-9 52-51