The season was extended one week, each team playing 17 games with one bye-week across the 18-week schedule.

2021 Regular Season Results

Date    OpponentResultScoreRecord
9/12vs MinnesotaW  27-24
OT
1-0
9/19at ChicagoL  17-20 1-1
9/26at PittsburghW  24-10 2-1
9/30vs JacksonvilleW  24-21 3-1
10/10vs Green BayL  22-25 3-2
10/17at DetroitW  34-11 4-2
10/24at BaltimoreW  41-17 5-2
10/31at NY JetsL  31-34 5-3
11/7vs ClevelandL  16-41 5-4
11/21at Las VegasW  32-13 6-4
11/28vs PittsburghW  41-10 7-4
12/5vs LA ChargersL  22-41 7-5
12/12vs San FranciscoL  23-26
OT
7-6
12/19at DenverW  15-10 8-6
12/26vs BaltimoreW  41-21 9-6
1/2vs Kansas CityW  34-31 10-6
1/9at ClevelandL  16-21 10-7