Due to a mid-season players' strike, the season was divided into a first half and a second half. The division winner of each half played each other in a five-game divisional series. The Cincinnati Reds, despite having the best overall record during the season, finished 2nd in both halves, so did not qualify for the post-season.

1981 Regular Season Results

Date    OpponentResultScoreRecord
4/10vs Chi. White SoxL  3-5 0-1
4/12vs Chi. White SoxW  5-4 1-1
4/13vs BaltimoreL  1-5 1-2
4/15vs BaltimoreW  7-2 2-2
4/17at Chi. White SoxW  8-5 3-2
4/18at Chi. White SoxL  1-2 3-3
4/19at Chi. White SoxW  9-4 4-3
4/20vs TexasW  4-2 5-3
4/21vs TexasW  10-4 6-3
4/22vs TexasL  8-16 6-4
4/25at BaltimoreL  2-7 6-5
4/26at BaltimoreW  7-5 7-5
4/27at TexasL  0-10 7-6
4/28at TexasL  0-9 7-7
4/29at TexasL  0-5 7-8
4/30vs MinnesotaL  4-8 7-9
5/1vs MinnesotaL  1-6 7-10
5/2vs MinnesotaL  2-11 7-11
5/3vs MinnesotaL  1-3 7-12
5/4at Kansas CityW  8-7
12
8-12
5/5at Kansas CityL  1-2 8-13
5/6at Kansas CityW  3-1 9-13
5/8at TorontoW  4-2 10-13
5/9at TorontoW  10-3 11-13
5/10at TorontoW  9-5
10
12-13
5/11at TorontoW  7-6 13-13
5/12at MinnesotaL  3-4
10
13-14
5/13at MinnesotaW  5-2 14-14
5/14at MinnesotaW  9-7
11
15-14
5/15vs Kansas CityW  4-3 16-14
5/16vs Kansas CityL  6-7 16-15
5/17vs Kansas CityL  4-5 16-16
5/18vs SeattleW  8-5 17-16
5/19vs SeattleW  4-0 18-16
5/20vs OaklandW  5-3 19-16
5/21vs OaklandW  3-0 20-16
5/22at MilwaukeeW  7-3 21-16
5/23at MilwaukeeW  8-1 22-16
5/24at MilwaukeeL  1-2
14
22-17
5/24at MilwaukeeL  7-10 22-18
5/25vs ClevelandW  8-7 23-18
5/26vs ClevelandL  2-5 23-19
5/27vs ClevelandW  10-5 24-19
5/29vs MilwaukeeL  4-5 24-20
5/30vs MilwaukeeW  7-6
10
25-20
5/31vs MilwaukeeL  2-5 25-21
6/2at ClevelandW  4-0 26-21
6/3at ClevelandL  1-4 26-22
6/4at ClevelandW  6-5 27-22
6/5at OaklandW  4-1 28-22
6/6at OaklandL  2-6 28-23
6/7at OaklandL  3-4
11
28-24
6/8at SeattleL  0-2 28-25
6/9at SeattleW  10-1 29-25
6/10at SeattleW  4-2 30-25
6/11at CaliforniaL  2-7 30-26
8/10vs Chi. White SoxL  1-7 30-27
8/11vs Chi. White SoxL  2-4 30-28
8/12vs Chi. White SoxW  8-1 31-28
8/13vs Chi. White SoxW  9-6 32-28
8/14at TexasL  2-3 32-29
8/15at TexasW  5-3
10
33-29
8/16at TexasL  0-3 33-30
8/18at OaklandL  2-3
15
33-31
8/19at OaklandL  2-4 33-32
8/20at OaklandW  6-4 34-32
8/21at SeattleW  7-4 35-32
8/22at SeattleW  5-3 36-32
8/23at SeattleW  7-5 37-32
8/24at CaliforniaL  6-8 37-33
8/25at CaliforniaL  7-8
10
37-34
8/27vs OaklandW  6-5 38-34
8/28vs OaklandW  12-5 39-34
8/29vs OaklandW  7-6 40-34
8/30vs OaklandL  3-5 40-35
8/31vs CaliforniaW  4-1 41-35
9/1vs CaliforniaL  2-3 41-36
9/2vs CaliforniaW  3-1 42-36
9/3vs SeattleL  7-8
20
42-37
9/4vs SeattleL  2-5 42-38
9/5vs SeattleW  12-5 43-38
9/6vs SeattleW  6-1 44-38
9/7at DetroitL  1-3 44-39
9/8at DetroitW  5-3 45-39
9/9at DetroitW  6-5
11
46-39
9/11at NY YankeesL  1-4 46-40
9/12at NY YankeesW  2-1 47-40
9/13at NY YankeesL  6-10 47-41
9/14vs DetroitW  5-2 48-41
9/16vs DetroitW  2-1
10
49-41
9/16vs DetroitW  5-4 50-41
9/17vs DetroitW  6-1 51-41
9/18vs NY YankeesL  4-6 51-42
9/19vs NY YankeesW  8-5 52-42
9/20vs NY YankeesW  4-1 53-42
9/21vs MilwaukeeW  9-3 54-42
9/22vs MilwaukeeL  8-10 54-43
9/23vs MilwaukeeW  11-5 55-43
9/24vs ClevelandL  2-5 55-44
9/25vs ClevelandW  5-4 56-44
9/26vs ClevelandL  5-7 56-45
9/27vs ClevelandL  7-8
11
56-46
9/28at MilwaukeeL  0-1 56-47
9/29at MilwaukeeW  7-2 57-47
9/30at MilwaukeeL  5-10 57-48
10/2at ClevelandL  4-11 57-49
10/3at ClevelandW  4-0 58-49
10/4at ClevelandW  6-2 59-49