In 1988, the St. Louis Cardinals left St. Louis for Phoenix, Arizona leaving St. Louis without a National Football League team. Looking to re-enter the league, St. Louis proposed building a domed stadium for a team to play in and attaching the Dome to the convention center to expand convention center capacity. The funding for the project was accomplished via public bonds beginning in 1989. In 1991, St. Louis put in for an NFL expansion franchise for 1995 called the St. Louis Stallions and began construction on The Dome in 1992. However, in 1993, the league chose Charlotte, North Carolina and Jacksonville, Florida over St. Louis.

After St. Louis came up short in its expansion bid, it appeared that the city might land a new team anyway. Advertising executive James Orthwein, a St. Louis native and member of the Busch family, bought the New England Patriots in 1992 from Victor Kiam to resolve a debt between the two men. The Patriots had long been in financial malaise since original owner Billy Sullivan, who was still the team president during Kiam's ownership, had squandered all of his net worth on a series of bad investments in the mid-1980s and was forced to sell the team to Kiam and Foxboro Stadium to Robert Kraft. Immediately upon purchase, Orthwein made it clear that he wanted to relocate the team from Foxborough, Massachusetts to St. Louis and was to leave New England at the end of the 1993 season. Orthwein's plans to move the team however were thwarted when Kraft refused to let Orthwein out of the long-term lease that he had secured from Kiam and Sullivan as part of his purchase of the stadium. Orthwein did not want to own the team if he could not move it, and Kraft initiated a hostile takeover that resulted in his purchase of the Patriots in 1994.

The then under-construction Dome finally received the NFL tenant it was looking for in 1995 when Georgia Frontiere announced she would relocate her Los Angeles Rams to St. Louis for the 1995 season. This move was initially voted down, with 21 opposed, three in favor (the Rams, Cincinnati Bengals and Tampa Bay Buccaneers), and six abstaining. The other owners (led by Buffalo's Ralph Wilson, the Jets’ Leon Hess, the Giants’ Wellington Mara, Washington's Jack Kent Cooke, Arizona's Bill Bidwill and Minnesota's John Skoglund) believed that the Rams’ financial problems were caused by the Frontieres’ mismanagement. When Frontiere threatened to sue the league, commissioner Paul Tagliabue acquiesced to Frontiere's demands. As part of the relocation deal, the city of St. Louis guaranteed that the stadium's amenities would be maintained in the top 25% of all NFL stadiums. After playing their first four home games of the 1995 season at Busch Memorial Stadium because the Dome was not ready, the Rams' first game in the stadium on Sunday, November 12, 1995 was a 28–17 win over the Carolina Panthers.

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