The park was rebuilt for the 1910 season as a concrete-and-steel stadium, one of two to open that year in the American League, the other being Comiskey Park. The new park seated over 18,000 people, more than double the seating capacity of its predecessor. It opened April 21, 1910, with a 5–0 loss to the Detroit Tigers in front of 18,832 fans in a game started by pitcher Cy Young.

During 1914 to 1915, the Toledo Mud Hens of the minor league American Association were temporarily moved to League Park, to discourage the Federal League from trying to place a franchise in Cleveland. During their two-year stay, they were initially known as the Bearcats, then the Spiders, reviving the old National League club's name.

In 1921, team owner "Sunny" Jim Dunn, who had purchased the team in 1916, renamed the park "Dunn Field". When Dunn died in 1922, his wife inherited the ballpark and the team. When Dunn's widow, by then known as Mrs. George Pross, sold the franchise in 1927 for $1 million to a group headed by Alva Bradley, the name reverted to the more prosaic "League Park" (there were a number of professional teams' parks generically called "league park" at the time).

From July 1932 through the 1933 season, the Indians played at the new and far larger Cleveland Stadium. However, the players and fans complained about the huge outfield, which reduced the number of home runs. Moreover, as the Great Depression worsened, attendance at the stadium plummeted. After the 1933 season, the Indians exercised their escape clause in the lease at the stadium and returned to League Park for the 1934 season.

The Indians played all home games at League Park for the 1934 and 1935 seasons, and played one home game at Cleveland Stadium in 1936 as part of the Great Lakes Exposition. In 1937, the Indians began splitting their schedule between the two parks, playing Sunday and holiday games at the stadium during the summer and the remainder at League Park, adding selected important games to the stadium schedule in 1938. Lights were never installed at League Park, and thus no major league night games were played there. However, at least one professional night game was played on July 27, 1931, between the Homestead Grays and the House of David, who borrowed the portable lighting system used by the Kansas City Monarchs.

By 1940, the Indians played most of their home schedule at Cleveland Stadium, abandoning League Park entirely after the 1946 season. The final Indians game at League Park was played on Saturday, September 21, a 5–3 loss in 11 innings to the Detroit Tigers in front of 2,772 fans. League Park became the last stadium used in Major League Baseball never to install permanent lights.

The Indians continued to own League Park until March 1950 when they sold it to the city of Cleveland for $150,000. After the demise of the Cleveland Buckeyes of the Negro American League during the 1950 season, League Park was no longer used as a regular sports venue. Most of the structure was demolished in 1951 by the city to convert the facility for use by local amateur teams and recreation and to prevent any competition with Cleveland Stadium. The lower deck seating between first base and third base remained, as did the Indians' clubhouse under the third base stands. The Cleveland Browns began using League Park as a practice field in 1952, including the former clubhouse, until 1965. All of the remaining seating areas were removed in 1961 except for the area above the former clubhouse, which was finally torn down in 2002.

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