The Civic Center is the full-time home of the Hartford Wolf Pack AHL hockey team and part-time home of the University of Connecticut (UConn) men's and women's basketball teams and the UConn Huskies men's ice hockey team. Starting in the late 1990s, UConn men's basketball moved most of their important games—including the bulk of their Big East Conference games—to the Coliseum. During the 2011–2012 season, for instance, they played 11 home games at the Coliseum and only eight at their on-campus facility, Gampel Pavilion. This practice continued when the Huskies joined the American Athletic Conference, successor to the original Big East, in 2013. The UConn men's hockey team uses the XL Center as its primary home as the newest men's member of Hockey East.

It was the home of the New England/Hartford Whalers of the WHA and NHL from 1975 to 1978 and 1980 to 1997, and the Hartford Hellions of the MISL from 1980 to 1981, and the New England Blizzard of the ABL from 1996 to 1998, and hosted occasional Boston Celtics home games from 1975 to 1995. It was the home of the Connecticut Coyotes and later the New England Sea Wolves of the Arena Football League.

The arena seats 15,635 for ice hockey and 16,294 for basketball, 16,606 for center-stage concerts, 16,282 for end-stage concerts, and 8,239 for ¾-end stage concerts, and contains 46 luxury suites and a 310-seat Coliseum Club, plus 25,000 square feet (2,300 m2) of arena floor space, enabling it to be used for trade shows and conventions in addition to concerts, circuses, ice shows, sporting events and other events. The graduation ceremonies of Central Connecticut State University and other local colleges are also held annually at the XL Center.

As originally built in 1975, it seated 10,507 for hockey, and served as the home of the then–New England Whalers for three years. In the early morning of January 18, 1978, the Civic Center's roof collapsed. Engineering analyses during litigation following the collapse indicated that compression members were overloaded through undersizing and underestimation of the probable loadings, and that lateral bracing of individual members was insufficient. "The roof did not fail due to the heavy snow that fell on that January night. According to the official City investigation, the roof began progressive failure as soon as it had been installed. Contributing factors included design errors, an underestimation of the weight of the roof, and differences between the design and the actual built structure."

Investigations attributed the design issues to the unprecedented use of and trust in computer analysis. An absence of peer review for the novel structure and design process, and fragmentation of oversight responsibility during construction were also cited as contributing factors. Evidence showed that the roof had started to fail during construction, with bowed compression members. These distortions, and an unpredicted degree of deflection in the structure, were not investigated before the collapse. There were no injuries due to the collapse. The building was heavily renovated and re-opened January 17, 1980.

The Arena hosted the Hartford Whalers from January 11, 1975 to April 13, 1997. Shortly thereafter the team relocated to Raleigh to become the Carolina Hurricanes. In 1994, new owner Peter Karmanos purchased the team and pledged to keep the Whalers in Connecticut until 1998, unless they could not sell over 11,000 season tickets. After failed negotiations to build a new downtown arena for the Whalers with then-Governor John G. Rowland, on March 25, 1997, Karmanos announced that the team would leave. The New York Rangers, looking to capitalize on Hartford as a potential market, placed its farm team there to become the Hartford Wolf Pack starting in 1997. After a short stint as the Connecticut Whale, they reverted to the Wolf Pack moniker in 2013. Renovations were complete in October 2014.

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