Hampton Coliseum was one of several former homes of the American Basketball Association Virginia Squires professional basketball franchise. The coliseum was also home to the Virginia Wings in the American Hockey League and Hampton Gulls in the Southern Hockey League and the Hampton Aces of the North Eastern Hockey League and Eastern Hockey League.

The coliseum hosted the Division I men's college basketball ECAC South Region Tournament, organized by the Eastern College Athletic Conference (ECAC), in 1980 and 1981. The 1985 Sun Belt Conference Men's Basketball Tournament and the 1987, 1988, and 1989 Colonial Athletic Association Men's Basketball Tournaments were held in the coliseum. The Old Dominion Monarchs basketball team played occasional games in the coliseum from 1970 to 1995, usually one game a year, although twice the team played several games in the coliseum, in the 1979–80 and 1984-85 seasons. The Hampton Coliseum is the home of the Virginia Duals annual wrestling tournament, hosting invitational college and high school matches.

The National Wrestling Alliance, WCW, WWE and other wrestling promotions have run shows at the Coliseum since the 1980s.

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