The stadium's design incorporates a former Hudson's warehouse, which was constructed in the 1920s. The warehouse was converted to office space and currently has Campbell Ewald and Bodman as tenants.

The presence of the warehouse allows for a seating arrangement that is unique among professional American football stadiums. The majority of suites are located in the warehouse along the stadium's southern sideline, as are the lounges that serve the premium club seats on that side of the field. The bulk of the grandstand seats are located along the northern sideline and both end-lines, with gaps in the stadium's upper half at the southwest and southeast corners. The upper deck on the stadium's northern sideline also contains one level of suites and a smaller section of club seating. A similar design was implemented at the renovated Soldier Field, albeit with the use of a new structure (as opposed to an existing building) to house four levels of suites.

Unlike most prior domed stadiums, Ford Field allows a large amount of natural light to reach the field, thanks to immense skylights and large glass windows at the open corners. The windows along the ceiling are frosted to mimic the automotive factories that are prevalent in Metro Detroit. The south entrance provides the seating bowl and concourse with sunlight year-round and also offers fans a view of downtown Detroit. To prevent the stadium from becoming an overly imposing presence in the Detroit skyline, the playing field is 45 feet (14 m) below street level, similar to the design at adjacent Comerica Park.

Ford Field is one of the few venues in the NFL that has end zones in the east and the west. There is no NFL rule for field construction in roofed venues regarding sunlight distracting players on the field. The east–west end zone design accommodated the Hudson warehouse location. The natural light is not a distraction to the players in a day game, because the light only reaches as far as the sidelines, leaving the field still properly lit with the combination of artificial stadium lighting and sunlight.

In 2017, Ford Field underwent its first major renovation. The $100 million renovation included new video boards, a new sound system, updated suites, and the renovation of multiple restaurants, clubs, and bars on the property.

🏟️