In January 1902, the Coliseum Garden Company procured a five-year lease from the Coliseum "to provide music and high class vaudeville entertainments" for the months of June, July, August and September.
Until 1908, the Coliseum hosted the notorious First Ward Ball, an annual political fundraiser for the two First Ward aldermen "Bathhouse" John Coughlin and Michael "Hinky Dink" Kenna – Coughlin and Kenna had been known as the "Lords of the Levee". Mayor Fred Busse was finally successful in halting the Ball in 1909.
From 1904 through 1920, this Coliseum hosted five consecutive Republican National Conventions, and the Progressive Party convention in 1912 and 1916.
During World War II, the army used the structure to house a radio training school which was previously in the nearby Stevens Hotel.
In 1926, the Coliseum built an ice rink at the arena to support professional ice hockey. The Coliseum hosted the Chicago Black Hawks of the National Hockey League (NHL) from 1926–1929 with a seating capacity of 6,000. It was also the home of the Chicago Cardinals (later renamed Chicago Americans) of the American Hockey Association (AHA) for the season of 1926–27 and the Chicago Shamrocks of the AHA from 1931–32. In June 1928, fight promoter Paddy Harmon announced plans to construct Chicago Stadium, with the Black Hawks as the marquee tenants.
As the 1928–29 NHL season approached, the Stadium was not yet ready, and Blackhawks owner Major Frederic McLaughlin had had a falling-out with Harmon. Consequently, the Blackhawks arranged to continue playing at the Coliseum. However, they could only get ice time through January 1929; they played the remainder of their "home" games in Detroit and in Fort Erie, Ontario, across the Niagara River from Buffalo.
The Blackhawks were back at the Coliseum as the 1929–30 season opened, but negotiations with the Stadium resumed in the fall of 1929 after Harmon was deposed as head of the Chicago Stadium Corporation. In December 1929, the team began play at the Stadium.
In 1932, another dispute led the Blackhawks to return temporarily to the Coliseum, for their first three home games of the 1932–33 campaign. On November 21, the Blackhawks defeated the Montreal Canadiens, 2–1, in their final game on Coliseum ice. Canadiens superstar Howie Morenz was the last player to score an NHL goal at the Coliseum, assisted by Aurel Joliat and Johnny Gagnon, at 7:06 of the second period.
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