Originally, the arena was home to the Anaheim Amigos of the American Basketball Association during the first ABA season, 1967–68. The franchise relocated to the Los Angeles Sports Arena and became the Los Angeles Stars immediately thereafter; the team eventually moved to Salt Lake City and became the Utah Stars, capturing the 1970–71 ABA Championship. The Stars' subsequent fan support in Utah set the foundation for the NBA's Utah Jazz. The San Diego Friars of WTT played some of their home matches in the arena between 1975 and 1977. In 1978, the Anaheim Oranges of WTT used the arena as their primary home venue. The arena was also home to the California Surf of the NASL for one indoor season (1979–80).

According to frequent news reports, the largest exposition held at the Convention Center in recent years has been the Winter NAMM Show. This music-equipment convention (trade only, not open to the general public) had 1,560 exhibitors and a record-breaking 88,100 attendees during the 2008 show. The NAMM Show has been running at the Anaheim Center since 1977, except for a three-year break in 1998–2000 while the Convention Center underwent major renovations. In 2008, news reports indicated that NAMM's long-term lease with the Anaheim Convention Center authority would end in 2010, and NAMM was applying pressure to the City of Anaheim to further expand and improve the convention center.

The Anime Expo was hosted at the Anaheim Convention Center in 1996 and again from 2003 through 2006 and was one of the convention center's biggest public events.

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