Sandy Alderson's journey in baseball is marked by his influential roles in the front office rather than on the field. He began his career in Major League Baseball with the Oakland Athletics, joining the organization in 1981. Initially serving as the team's general counsel, Alderson's legal background and analytical approach quickly became assets to the Athletics. By 1983, he had ascended to the role of general manager, a position he held until 1997.

During his tenure with the Athletics, Alderson was instrumental in implementing a data-driven approach to team management, which later became known as sabermetrics. This analytical strategy focused on empirical data and statistics to evaluate players and make informed decisions, a method that was relatively novel at the time. Under his leadership, the Athletics experienced a period of success, including three consecutive World Series appearances from 1988 to 1990 and a championship win in 1989.

Alderson's innovative approach to team building and management caught the attention of other organizations. In 1998, he joined Major League Baseball's central office as the executive vice president of baseball operations. In this role, Alderson was responsible for overseeing the league's baseball operations, including umpiring, on-field discipline, and other administrative functions. His tenure at the MLB office was marked by efforts to improve the efficiency and fairness of the game.

In 2005, Alderson returned to team management when he was appointed CEO of the San Diego Padres. During his time with the Padres, he continued to emphasize the importance of analytics and player development. Although the team did not achieve significant postseason success during his tenure, Alderson's influence helped shape the organization's long-term strategy.

Alderson's career took another turn in 2010 when he was hired as the general manager of the New York Mets. Tasked with revitalizing a struggling franchise, he focused on rebuilding the team's farm system and financial stability. Under his guidance, the Mets reached the World Series in 2015, although they were ultimately defeated by the Kansas City Royals. Alderson stepped down as general manager in 2018 due to health concerns but remained with the organization in an advisory capacity.

In 2020, Alderson returned to the Mets as team president, overseeing the team's baseball and business operations.