Ryan Doumit's journey in Major League Baseball began when he was drafted by the Pittsburgh Pirates in the second round of the 1999 MLB Draft. A switch-hitting catcher, Doumit made his MLB debut with the Pirates on June 5, 2005. Over the next several years, he became known for his offensive capabilities, particularly his power and ability to hit for average, which were somewhat atypical for a catcher.

During his tenure with the Pirates, Doumit displayed versatility by playing multiple positions, including first base and right field, in addition to his primary role as a catcher. This flexibility allowed the Pirates to utilize his bat in the lineup even when he wasn't behind the plate. Doumit's best season with the Pirates came in 2008 when he posted a .318 batting average, hit 15 home runs, and drove in 69 runs over 116 games. His performance that year highlighted his potential as a valuable offensive player.

Injuries, however, were a recurring issue throughout Doumit's career. He faced several stints on the disabled list, which affected his ability to maintain consistent playing time. Despite these setbacks, Doumit remained a productive player when healthy, providing a solid offensive presence for the Pirates.

After seven seasons with Pittsburgh, Doumit's time with the team came to an end when he signed a one-year contract with the Minnesota Twins in November 2011. His tenure with the Twins saw him continue to contribute offensively, as he hit 18 home runs and drove in 75 runs during the 2012 season. Doumit's ability to play multiple positions was again an asset, as he split time between catcher, designated hitter, and the outfield.

Doumit played two seasons with the Twins before being traded to the Atlanta Braves in December 2013. In Atlanta, he served primarily as a backup catcher and pinch hitter. His final season in the majors was in 2014 with the Braves, after which he did not return to MLB play.

Throughout his career, Doumit was known for his offensive skills and adaptability on the field.