Reggie Sanders, a right-handed outfielder, embarked on his Major League Baseball journey with the Cincinnati Reds. Drafted in the seventh round of the 1987 MLB Draft, Sanders made his debut with the Reds in 1991. His early years with Cincinnati showcased his potential as a power hitter and a reliable presence in the outfield. In 1995, Sanders had a standout season, earning a spot on the National League All-Star team. That year, he hit 28 home runs, drove in 99 runs, and maintained a batting average of .306, helping the Reds secure a division title.

Following his tenure with the Reds, Sanders joined the San Diego Padres in 1999. Although his time with the Padres was brief, he continued to demonstrate his ability to contribute both offensively and defensively. In 2000, Sanders signed with the Atlanta Braves, where he played a crucial role in their postseason run. His performance in the National League Championship Series was particularly noteworthy, as he hit .500 with two home runs.

Sanders' career took him to the Arizona Diamondbacks in 2001. During his time with the Diamondbacks, he was part of the team that won the World Series, defeating the New York Yankees in a thrilling seven-game series. Sanders' contributions during the regular season and playoffs were instrumental in Arizona's championship success.

In 2002, Sanders moved to the San Francisco Giants, where he continued to be a valuable asset. His tenure with the Giants was marked by consistent offensive production and solid defensive play. Sanders then signed with the Pittsburgh Pirates in 2003, where he played for one season before joining the St. Louis Cardinals in 2004.

With the Cardinals, Sanders experienced a resurgence in his career. In 2004, he hit 22 home runs and drove in 67 runs, helping St. Louis reach the World Series. Although the Cardinals fell short against the Boston Red Sox, Sanders' performance was a highlight of their postseason campaign. He remained with the Cardinals through the 2005 season, continuing to provide veteran leadership and offensive firepower.

Sanders' final MLB stop was with the Kansas City Royals, where he played from 2006 to 2007. Despite battling injuries during his time with the Royals, he managed to achieve a significant career milestone by joining the 300 home run and 300 stolen base club, a testament to his power and speed.

Throughout his career, Sanders was known for his ability to adapt to different teams and situations. His combination of power, speed, and defensive skills made him a valuable player for every team he joined.