Ramon Castro, a catcher from Vega Baja, Puerto Rico, made his entry into Major League Baseball (MLB) when he was drafted by the Houston Astros in the first round of the 1994 MLB Draft. However, it was with the Florida Marlins that he would make his MLB debut. Castro's debut came on September 1, 1999, marking the beginning of his career in the major leagues.

During his time with the Marlins, Castro served primarily as a backup catcher. His role was to provide depth and support behind the plate, and he was known for his strong arm and defensive skills. While his batting average was not particularly high, he demonstrated occasional power, hitting home runs that contributed to his team's efforts. Castro's tenure with the Marlins lasted until 2004, during which he experienced the highs and lows of a developing career.

In 2005, Castro joined the New York Mets, where he continued to serve as a backup catcher. His time with the Mets was marked by several memorable moments, including a walk-off home run against the Los Angeles Angels in June 2005. This particular home run was a highlight of his career, showcasing his ability to deliver in clutch situations. Castro's presence in the Mets' lineup provided the team with a reliable option behind the plate, and he became a fan favorite for his enthusiastic play and occasional offensive bursts.

Castro's role with the Mets remained consistent over the years, as he provided support to the team's starting catchers. His defensive skills were often praised, and he was regarded as a dependable catcher who could handle the pitching staff effectively. Despite not being a regular starter, Castro's contributions were valued by his teammates and coaches alike.

In 2009, Castro was traded to the Chicago White Sox, where he continued his career as a backup catcher. His time with the White Sox was relatively short, but he managed to make an impression with his defensive capabilities and occasional power at the plate. Castro's experience and knowledge of the game were assets to the team, and he provided veteran leadership in the clubhouse.

Castro returned to the Mets briefly in 2009 before being traded to the Chicago White Sox once again in 2010. His second stint with the White Sox saw him continue in his familiar role as a backup catcher. Despite limited playing time, Castro's presence was appreciated by the team, and he remained a respected figure in the dugout.

Throughout his career, Ramon Castro was known for his defensive prowess and ability to handle pitchers effectively. While his offensive numbers were not standout, his occasional power and timely hits added value to the teams he played for. Castro's career in MLB spanned over a decade, during which he played for several teams and left a lasting impression as a reliable and experienced catcher.

After the 2011 season, Castro's playing days in the major leagues came to an end.