Nelson Briles, a right-handed pitcher, began his Major League Baseball career with the St. Louis Cardinals. He made his debut in 1965, quickly establishing himself as a reliable arm in the Cardinals' pitching rotation. Briles' early years with the team were marked by steady improvement, and he played a crucial role in the Cardinals' success during the late 1960s.

In 1967, Briles had a standout season, posting a 14-5 record with a 2.43 ERA. His performance helped the Cardinals secure the National League pennant, and he was instrumental in their World Series victory over the Boston Red Sox. Briles pitched a complete-game shutout in Game 3 of the series, showcasing his ability to perform under pressure on baseball's biggest stage.

The following year, Briles continued to be a valuable asset for the Cardinals, contributing to their return to the World Series in 1968. Although the team fell to the Detroit Tigers in a seven-game series, Briles' efforts throughout the season were commendable. He finished the year with a 19-11 record and a 2.81 ERA, further solidifying his reputation as a dependable pitcher.

In 1970, Briles was traded to the Pittsburgh Pirates, where he continued to demonstrate his pitching prowess. During his tenure with the Pirates, he was part of the team that won the 1971 World Series against the Baltimore Orioles. Briles' performance in Game 5 of the series was particularly memorable, as he pitched a two-hit shutout, helping the Pirates take a crucial lead in the series.

After his time with the Pirates, Briles went on to play for the Kansas City Royals, Texas Rangers, and Baltimore Orioles. While his later years in the league were not as dominant as his earlier seasons, he remained a valuable player, known for his experience and ability to mentor younger pitchers.

Briles retired from professional baseball in 1978, leaving behind a legacy of consistency and excellence on the mound.

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