Ned Yost's journey in professional baseball began when he was drafted by the New York Mets in the first round of the 1974 amateur draft. However, it was with the Milwaukee Brewers that he made his Major League debut in 1980. As a catcher, Yost played six seasons in the majors, spending time with the Brewers, Texas Rangers, and Montreal Expos. His playing career was characterized by his role as a backup catcher, where he provided depth and support to the teams he played for.

After retiring as a player, Yost transitioned into coaching, where he found a new avenue to contribute to the sport. He joined the Atlanta Braves organization, working under manager Bobby Cox. Yost served as the Braves' bullpen coach from 1991 to 1998 and then as the third base coach from 1999 to 2002. During his tenure with the Braves, the team experienced significant success, including multiple playoff appearances and a World Series championship in 1995.

In 2003, Yost took on the role of manager for the Milwaukee Brewers. His time with the Brewers saw the team gradually improve, culminating in a winning season in 2007, their first since 1992. Yost's managerial style focused on developing young talent and fostering a competitive environment. However, in September 2008, with the Brewers in the midst of a playoff race, Yost was unexpectedly dismissed from his position.

Yost's managerial career continued when he was hired by the Kansas City Royals in 2010. Under his leadership, the Royals underwent a transformation, culminating in back-to-back World Series appearances in 2014 and 2015. The 2014 season saw the Royals make a remarkable postseason run, ultimately falling to the San Francisco Giants in the World Series. The following year, Yost guided the Royals to their first World Series championship since 1985, defeating the New York Mets in five games.

Throughout his managerial career, Yost was known for his strategic decisions and ability to manage a bullpen effectively.