Mohamed Sanu's journey in professional football began when he was drafted by the Cincinnati Bengals in the third round of the 2012 NFL Draft. A wide receiver from Rutgers University, Sanu quickly became known for his reliable hands and ability to make plays in critical situations. During his time with the Bengals, he developed a reputation as a dependable target, contributing to the team's offensive efforts with his receiving skills and occasional trick plays, including passing touchdowns.

Sanu's tenure with the Bengals lasted until 2015, during which he played a crucial role in the team's passing game. His versatility on the field allowed him to line up in various positions, making him a valuable asset to the Bengals' offensive strategy. In 2016, Sanu signed a five-year contract with the Atlanta Falcons, marking a new chapter in his career.

With the Falcons, Sanu continued to demonstrate his abilities as a wide receiver. He played an integral part in the Falcons' journey to Super Bowl LI, where they faced the New England Patriots. Although the Falcons did not secure the championship, Sanu's performance throughout the season was commendable. He remained with the Falcons until 2019, consistently contributing to the team's offensive plays and providing leadership on and off the field.

In October 2019, Sanu was traded to the New England Patriots, where he joined a team known for its strategic gameplay and strong leadership. His time with the Patriots was relatively short, as he was released by the team in September 2020. Despite this, Sanu's experience and skills were recognized by other teams in the league.

Shortly after his release from the Patriots, Sanu signed with the San Francisco 49ers. His stint with the 49ers was brief, and he was released in October 2020. However, Sanu's career continued as he rejoined the Detroit Lions, a team he had briefly been a part of earlier in the year. His role with the Lions allowed him to bring his veteran experience to a young team, contributing both on the field and in the locker room.

In 2021, Sanu returned to the San Francisco 49ers, where he played until he was placed on injured reserve in November of that year. Throughout his career, Sanu was known for his ability to perform under pressure and his knack for executing trick plays, including several successful passing attempts that showcased his versatility as a player.

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