Mike Matheny's journey in Major League Baseball began when he was drafted by the Milwaukee Brewers in the eighth round of the 1991 MLB Draft. He made his debut with the Brewers in 1994, quickly establishing himself as a reliable catcher. Matheny's defensive skills were particularly noteworthy, earning him a reputation as one of the best defensive catchers in the league during his playing years.

After his stint with the Brewers, Matheny signed with the Toronto Blue Jays in 1999. His time in Toronto was brief, but he continued to demonstrate his defensive prowess behind the plate. In 2000, Matheny joined the St. Louis Cardinals, where he would spend the most significant portion of his playing career. It was with the Cardinals that Matheny truly excelled defensively, winning three consecutive Gold Glove Awards from 2000 to 2002. His ability to manage the pitching staff and control the game from behind the plate was highly regarded.

Matheny's tenure with the Cardinals also saw him participate in the postseason, including the 2004 World Series. Although the Cardinals did not win the championship that year, Matheny's leadership and defensive skills were instrumental in their journey to the Fall Classic. In 2005, he signed with the San Francisco Giants, where he continued to play until 2006. During his time with the Giants, Matheny added another Gold Glove Award to his collection in 2005, further solidifying his reputation as an elite defensive catcher.

Unfortunately, Matheny's playing career was cut short due to concussion-related issues, leading to his retirement in 2006. Despite the early end to his playing days, Matheny's influence on the field was undeniable, particularly in his ability to guide pitchers and manage games from behind the plate.

Transitioning from player to manager, Matheny took on the role of managing the St. Louis Cardinals in 2012. In his first year as manager, he led the team to the National League Championship Series. Under his leadership, the Cardinals reached the postseason in four of his first five seasons, including a trip to the World Series in 2013, where they were defeated by the Boston Red Sox.

Matheny's managerial career with the Cardinals lasted until 2018, when he was relieved of his duties. However, his time as a manager was marked by a strong regular-season record and a reputation for developing young talent. In 2020, Matheny returned to the managerial ranks, taking over as the manager of the Kansas City Royals. His tenure with the Royals focused on rebuilding and developing a competitive team for the future.