Born on February 24, 1974, in San Juan, Puerto Rico, Mike Lowell grew up in a family with a rich baseball heritage. His father, Carl Lowell, played in the Puerto Rican leagues, and his Cuban ancestry further deepened his connection to the sport. Mike attended Coral Gables High School in Florida, where he excelled in baseball, earning a scholarship to Florida International University (FIU). At FIU, Lowell's talent on the field became evident, and he was named an All-American, setting the stage for his professional career.

The New York Yankees selected Lowell in the 20th round of the 1995 MLB Draft. He spent several years in the Yankees' minor league system, honing his skills and demonstrating his potential as a third baseman. In 1998, Lowell made his Major League debut with the Yankees, appearing in eight games. However, with the Yankees' roster stacked with talent, opportunities for Lowell were limited.

In February 1999, Lowell's career took a significant turn when he was traded to the Florida Marlins. It was with the Marlins that Lowell began to establish himself as a reliable and productive player. Over the next several seasons, he became a fixture at third base, known for his solid defense and consistent hitting. In 2003, Lowell played a crucial role in the Marlins' unexpected run to the World Series title. Despite suffering a broken hand late in the season, he returned to contribute in the postseason, helping the Marlins defeat the New York Yankees in the World Series.

Lowell's performance with the Marlins earned him recognition, including multiple All-Star selections. However, following the 2005 season, the Marlins underwent a roster overhaul, and Lowell was traded to the Boston Red Sox along with pitcher Josh Beckett. The move to Boston proved to be a turning point in Lowell's career.

With the Red Sox, Lowell continued to excel both offensively and defensively. In 2007, he had one of his best seasons, batting .324 with 21 home runs and 120 RBIs. His performance was instrumental in leading the Red Sox to the postseason. During the 2007 World Series, Lowell's contributions were vital as the Red Sox swept the Colorado Rockies to win the championship. For his efforts, Lowell was named the World Series MVP, cementing his place in Red Sox lore.

Lowell's tenure with the Red Sox was marked by consistent play and leadership. He was respected by teammates and fans alike for his professionalism and work ethic. However, as he entered the latter stages of his career, injuries began to take a toll. Despite these challenges, Lowell remained a valuable player for the Red Sox until his retirement.

In 2010, Lowell announced his retirement from professional baseball. Over his career, he accumulated a .279 batting average, 223 home runs, and 952 RBIs.