Mike Lamb, a left-handed hitter known for his steady presence at the plate, embarked on his Major League Baseball career after being drafted by the Texas Rangers in the seventh round of the 1997 MLB Draft. He made his debut with the Rangers on April 23, 2000, stepping into the major leagues as a third baseman. During his time with Texas, Lamb demonstrated a consistent ability to get on base, posting a .288 batting average in his rookie season.

In 2004, Lamb's career took a new direction when he was traded to the New York Yankees, although he never played a regular-season game for them. Shortly after, he was traded to the Houston Astros, where he found a more permanent home. Lamb's tenure with the Astros marked a period of stability and productivity. He played a crucial role in the Astros' lineup, particularly during the 2005 season when the team made its first-ever World Series appearance. Lamb hit .233 with 12 home runs and 53 RBIs that year, contributing to the Astros' success with his reliable bat and ability to play multiple infield positions.

Lamb's performance in the 2005 postseason was memorable. In Game 1 of the World Series against the Chicago White Sox, he hit a pinch-hit home run, showcasing his knack for delivering in high-pressure situations. Although the Astros ultimately fell to the White Sox, Lamb's efforts during the playoffs were a highlight of his career.

After his stint with the Astros, Lamb signed with the Minnesota Twins in 2008. However, his time with the Twins was short-lived, as he struggled to maintain his previous level of performance. He was released by the Twins later that year and subsequently signed with the Milwaukee Brewers. Lamb's role with the Brewers was primarily as a bench player, and he finished the 2008 season with a combined batting average of .235.

In 2009, Lamb signed a minor league contract with the New York Mets but was released before the season began. He then joined the Florida Marlins, where he played sparingly, appearing in just 43 games. Despite limited playing time, Lamb managed to hit .261, demonstrating his ability to contribute offensively when called upon.

Lamb's final major league appearance came in 2010 with the Marlins. After being released mid-season, he signed a minor league deal with the Yankees but did not make it back to the majors. Over his career, Lamb compiled a .276 batting average, with 69 home runs and 349 RBIs. His ability to adapt to different roles and provide depth to the teams he played for was a testament to his skills as a professional baseball player.

Throughout his career, Lamb was known for his professionalism and work ethic.