Marcus Gilchrist embarked on his professional football journey when he was selected by the San Diego Chargers in the second round of the 2011 NFL Draft. A product of Clemson University, Gilchrist entered the league with a reputation for being a reliable defensive back. During his time with the Chargers, he played both safety and cornerback, showcasing his adaptability on the field. His tenure with the Chargers lasted four seasons, during which he accumulated valuable experience and honed his skills in the defensive backfield.

In 2015, Gilchrist signed with the New York Jets, where he continued to demonstrate his abilities as a safety. His first season with the Jets was marked by a solid performance, as he started all 16 games and recorded three interceptions, contributing to the team's defensive efforts. Gilchrist's time with the Jets, however, was cut short due to a knee injury in 2016, leading to his release from the team in 2017.

Following his departure from the Jets, Gilchrist joined the Houston Texans for the 2017 season. During his stint with the Texans, he played in all 16 games, starting in 13 of them. His presence in the secondary provided stability and experience to the Texans' defense. After his year in Houston, Gilchrist moved on to the Oakland Raiders in 2018, where he continued to be a reliable option in the defensive backfield, appearing in all 16 games.

In 2019, Gilchrist signed with the Detroit Lions, adding depth to their secondary. Although his time with the Lions was brief, he managed to contribute to the team in a backup role. Throughout his career, Gilchrist was known for his ability to adapt to different defensive schemes and his willingness to play multiple positions in the secondary.

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