Lou Guisto, a first baseman in Major League Baseball, played during the early 20th century. Born on January 16, 1895, in Napa, California, Guisto's journey in professional baseball began when he joined the Cleveland Indians. His debut in the major leagues came on September 22, 1916, marking the start of his career at the highest level of the sport.

Guisto's time with the Cleveland Indians spanned several seasons, although his appearances were sporadic. In the 1916 season, he played in just a handful of games, but this initial exposure to major league baseball set the stage for future opportunities. After a brief hiatus from the majors, he returned to the Indians in 1921. During this period, Guisto saw more playing time, participating in 70 games and achieving a batting average of .196. Despite the challenges of maintaining a consistent presence in the lineup, he demonstrated his abilities on the field, particularly in his defensive role at first base.

The 1922 season saw Guisto continue with the Cleveland Indians, although his time on the field was limited. He played in 28 games and managed a batting average of .208. While his offensive statistics may not have stood out, his role as a first baseman was valued for his defensive skills and reliability.

In 1923, Lou Guisto's major league career came to a close. Over the course of his time with the Cleveland Indians, he played in a total of 132 games, achieving a career batting average of .196. While his tenure in Major League Baseball was relatively brief, Guisto's involvement in the sport extended beyond his playing days. After retiring from professional baseball, he continued to contribute to the game by coaching and mentoring young players.

Lou Guisto's legacy in baseball is also remembered through his connection to the University of California, Berkeley, where he played college baseball before turning professional. His contributions to the sport at the collegiate level were recognized when he was inducted into the Cal Athletic Hall of Fame.

Throughout his career, Lou Guisto experienced the challenges and triumphs of professional baseball during a transformative period in the sport's history.