Kameron Loe, a towering right-handed pitcher, made his Major League Baseball debut with the Texas Rangers. Standing at 6 feet 8 inches, Loe's height and pitching style made him a distinctive presence on the mound. He was drafted by the Rangers in the 20th round of the 2002 MLB Draft out of California State University, Northridge, and quickly worked his way through the minor leagues.

Loe's MLB debut came on September 26, 2004, when he pitched for the Rangers against the Seattle Mariners. Over the next few seasons, he became a regular part of the Rangers' pitching staff, both as a starter and a reliever. His versatility allowed him to fill various roles, although he primarily served as a reliever. Loe's best season with the Rangers came in 2005 when he posted a 3.42 ERA over 48 appearances, including eight starts.

In 2008, Loe signed with the Fukuoka SoftBank Hawks of Nippon Professional Baseball in Japan, seeking to refine his skills and gain more experience. His time in Japan was brief, and he returned to the United States the following year. In 2010, Loe signed a minor league contract with the Milwaukee Brewers and was called up to the majors in June. He became a reliable bullpen option for the Brewers, posting a 2.78 ERA in 58 appearances that season.

Loe continued to pitch for the Brewers through the 2012 season, providing steady relief work. In 2011, he helped the team reach the National League Championship Series, appearing in 72 games with a 3.50 ERA. His ability to induce ground balls was a key aspect of his pitching style, often relying on a sinker to get batters out.

After his tenure with the Brewers, Loe's career included brief stints with several other MLB teams. In 2013, he signed with the Seattle Mariners but was designated for assignment after a few appearances. He then joined the Chicago Cubs and later the Atlanta Braves, though his time with each team was short-lived.

Loe's major league career concluded after the 2013 season, but he continued to play professionally in various leagues, including minor league teams and independent leagues. His journey through baseball was marked by adaptability and a willingness to embrace different roles on the pitching staff.