John Vukovich's journey in Major League Baseball began when he was drafted by the Philadelphia Phillies in the first round of the 1966 MLB Draft. Known primarily for his defensive skills, Vukovich played as a third baseman. His major league debut came on September 11, 1970, with the Phillies. Although his batting average was modest, his defensive prowess was well-regarded by teammates and coaches alike.

Throughout his playing career, Vukovich was part of several teams. After his initial stint with the Phillies, he was traded to the Milwaukee Brewers in 1973. His time with the Brewers was brief, and he returned to the Phillies in 1975. The following year, he was traded to the Cincinnati Reds, where he was part of the team during their 1976 World Series championship season. Although he did not play in the postseason, being part of the "Big Red Machine" was a notable experience in his career.

Vukovich's playing career was characterized by frequent transitions between the major and minor leagues. Despite these challenges, he remained a respected figure in the dugout for his understanding of the game and his ability to mentor younger players. His final appearance as a player came in 1981 with the Phillies, marking the end of a career that spanned over a decade.

After retiring as a player, Vukovich transitioned into coaching, where he found a long-term role with the Phillies. He served as a coach for the team from 1983 to 1987 and again from 1988 to 2004. His tenure as a coach was marked by his deep knowledge of the game and his ability to communicate effectively with players. Vukovich was part of the coaching staff during the Phillies' 1993 National League Championship season, which culminated in a World Series appearance.

In addition to his time with the Phillies, Vukovich also had coaching stints with the Chicago Cubs. His reputation as a coach was built on his attention to detail and his commitment to helping players improve their skills. Vukovich's influence extended beyond the field, as he was known for his leadership and his ability to foster a positive team environment.