Joe Magrane's journey in Major League Baseball began when he was drafted by the St. Louis Cardinals as the 18th overall pick in the first round of the 1985 MLB Draft. A left-handed pitcher, Magrane quickly made his way through the minor leagues, showcasing his potential and earning a spot on the Cardinals' roster. He made his MLB debut on April 25, 1987, against the Montreal Expos, marking the start of his professional career.

In his rookie season, Magrane demonstrated his pitching prowess by finishing with a 9-7 record and a 3.54 ERA. His performance helped the Cardinals reach the postseason, where they advanced to the World Series. Although the Cardinals ultimately fell to the Minnesota Twins, Magrane's efforts did not go unnoticed, and he finished third in the National League Rookie of the Year voting.

The following year, Magrane continued to develop as a pitcher. In 1988, he led the National League with a 2.18 ERA, despite a modest 5-9 win-loss record. His ERA title was a testament to his ability to limit opposing teams' scoring opportunities, even when run support from his own team was lacking. This achievement highlighted his skill and potential as a top-tier pitcher in the league.

Magrane's career, however, was not without its challenges. Injuries began to take a toll on his performance and availability. In 1989, he was limited to just 24 starts due to arm issues, but he still managed to post a respectable 3.08 ERA. The early 1990s saw Magrane struggle with injuries, which affected his consistency and effectiveness on the mound.

In 1993, Magrane was traded to the California Angels, where he hoped to revitalize his career. During his time with the Angels, he worked to regain his form, but injuries continued to hinder his progress. Despite these setbacks, he remained a valuable member of the pitching staff, providing veteran leadership and experience.

Magrane's tenure with the Angels lasted until 1995, after which he signed with the Chicago White Sox. His time with the White Sox was brief, as he appeared in only a handful of games before being released. He then signed with the Seattle Mariners, where he concluded his MLB career in 1996.

Throughout his career, Joe Magrane was known for his pitching intelligence and ability to adapt to different situations on the field. While injuries may have curtailed his time in the major leagues, his early achievements and perseverance left a lasting impression on those who followed his career.

After retiring from professional baseball, Magrane transitioned to a career in broadcasting. He became a well-regarded analyst, sharing his insights and knowledge of the game with fans. His post-playing career in broadcasting allowed him to remain connected to the sport he loved, providing commentary and analysis for various networks, including MLB Network.

Joe Magrane's baseball career was marked by moments of brilliance and the challenges of overcoming injuries.