Jerry Dipoto's journey in professional baseball began when he was drafted by the Cleveland Indians in the third round of the 1989 MLB Draft. As a right-handed pitcher, Dipoto made his Major League debut with the Indians on May 11, 1993. His time with Cleveland was marked by steady development, as he worked to establish himself as a reliable option out of the bullpen.

In 1994, Dipoto was traded to the New York Mets, where he continued to hone his skills as a relief pitcher. During his tenure with the Mets, he demonstrated his ability to handle pressure situations, often being called upon in late innings. His performance with the Mets was solid, and he became a dependable part of their bullpen rotation.

Dipoto's career took another turn in 1997 when he was traded to the Colorado Rockies. Pitching at Coors Field, known for its hitter-friendly conditions, presented new challenges. Despite the difficulties of pitching in such an environment, Dipoto managed to maintain respectable numbers and became a valuable asset to the Rockies' bullpen. His time in Colorado was marked by perseverance and adaptability, as he adjusted his pitching style to better suit the high-altitude conditions.

After his stint with the Rockies, Dipoto signed with the Arizona Diamondbacks in 2000. His experience and leadership were assets to the Diamondbacks' bullpen, and he played a role in helping the team reach the postseason. Unfortunately, health issues began to take a toll on his playing career, and he retired from professional baseball in 2001.

Following his retirement as a player, Dipoto transitioned into a front-office role, where he found a new avenue to contribute to the sport. He began his executive career with the Boston Red Sox as a scout, before moving on to the Colorado Rockies as the Director of Player Personnel. His keen eye for talent and understanding of the game led to further opportunities, and he eventually joined the Arizona Diamondbacks as the Vice President of Player Personnel.

In 2010, Dipoto was named the interim General Manager of the Diamondbacks, a role in which he demonstrated his aptitude for team management and player evaluation. His success in this position paved the way for his appointment as the General Manager of the Los Angeles Angels in 2011. During his tenure with the Angels, Dipoto focused on building a competitive roster, making strategic trades, and investing in player development.

Dipoto's career took another significant step forward in 2015 when he was hired as the General Manager of the Seattle Mariners. In Seattle, he was known for his aggressive approach to roster construction, frequently making trades to improve the team's competitiveness. His tenure with the Mariners was characterized by a commitment to building a sustainable and successful organization, with a focus on both immediate success and long-term development.