Jed Lowrie's journey in Major League Baseball began when he was drafted by the Boston Red Sox in the first round of the 2005 MLB Draft. A switch-hitting infielder, Lowrie made his MLB debut with the Red Sox in 2008. During his initial years with Boston, he demonstrated his ability to play multiple infield positions, primarily shortstop and second base. His rookie season saw him stepping up in crucial moments, including the postseason, where he contributed to the team's efforts in the American League Championship Series.

Injuries, however, were a recurring theme throughout Lowrie's career. Despite these setbacks, he managed to maintain a presence in the league. After his stint with the Red Sox, Lowrie was traded to the Houston Astros in 2011. His time with the Astros was marked by a solid offensive performance, though injuries continued to limit his playing time.

Lowrie's career took another turn when he was traded to the Oakland Athletics in 2012. It was with the A's that he found a more consistent role, particularly during the 2013 season when he played in a career-high 154 games. That year, he posted impressive offensive numbers, including a .290 batting average, 15 home runs, and 75 RBIs. His performance helped the Athletics secure a playoff berth, and he became a reliable fixture in their lineup.

In 2015, Lowrie returned to the Astros for a brief period before being traded back to the Athletics in 2016. His second stint with Oakland proved fruitful, as he enjoyed some of his best seasons there. The 2017 and 2018 seasons were particularly productive, with Lowrie earning his first All-Star selection in 2018. That year, he hit 23 home runs and drove in 99 runs, both career highs, while playing primarily at second base.

Lowrie's career faced another challenge when he signed with the New York Mets in 2019. Unfortunately, injuries severely limited his time on the field, and he appeared in only nine games over two seasons with the team. In 2021, Lowrie returned to the Athletics for a third time, where he managed to play a more substantial role, appearing in 139 games and providing veteran leadership to a young team.

Throughout his career, Lowrie was known for his ability to switch-hit and his adaptability in the infield.