James Loney's journey in Major League Baseball began when he was drafted by the Los Angeles Dodgers in the first round of the 2002 MLB Draft. Known for his smooth left-handed swing and solid defensive skills at first base, Loney quickly rose through the ranks of the Dodgers' minor league system. By 2006, he made his debut in the major leagues, showcasing his potential as a reliable hitter and fielder.

Loney's breakout season came in 2007 when he became a regular starter for the Dodgers. That year, he posted a .331 batting average with 15 home runs and 67 RBIs in 96 games. His performance helped the Dodgers reach the postseason, and he continued to be a consistent presence in their lineup over the next several years. Loney was known for his ability to hit for average and his knack for driving in runs, often coming through in clutch situations.

Throughout his time with the Dodgers, Loney was a steady performer, providing solid defense at first base and contributing offensively. He played with the team until 2012, when he was traded to the Boston Red Sox as part of a blockbuster deal. His stint with the Red Sox was brief, as he became a free agent at the end of the season.

In 2013, Loney signed with the Tampa Bay Rays, where he enjoyed a resurgence in his career. He played three seasons with the Rays, consistently hitting for average and providing veteran leadership to a young team. During his time in Tampa Bay, Loney was praised for his professionalism and work ethic, traits that made him a respected figure in the clubhouse.

After his tenure with the Rays, Loney had brief stints with the New York Mets and the San Diego Padres. While his offensive numbers declined in the latter part of his career, he remained a reliable defensive player and a positive influence on his teammates.