Greg Colbrunn's journey in Major League Baseball began when he was drafted by the Montreal Expos in the sixth round of the 1987 MLB Draft. A right-handed first baseman and occasional catcher, Colbrunn made his MLB debut with the Expos on July 9, 1992. His time with Montreal was brief, but it marked the start of a career that would see him play for several teams over the next decade.

After his stint with the Expos, Colbrunn was traded to the Florida Marlins in 1993. It was with the Marlins that he began to establish himself as a reliable hitter. During the 1994 season, Colbrunn posted a .290 batting average, demonstrating his ability to contribute offensively. His performance with the Marlins helped solidify his reputation as a solid player, capable of delivering consistent at-bats.

In 1997, Colbrunn signed with the Minnesota Twins, but his time there was short-lived. He was traded mid-season to the Atlanta Braves, where he played a role in their successful campaign to reach the National League Championship Series. Although primarily a first baseman, Colbrunn's versatility allowed him to fill in at various positions, providing depth to the Braves' roster.

Colbrunn's most productive years came during his tenure with the Arizona Diamondbacks, which began in 1999. Over the next four seasons, he became known for his ability to hit for average and power. In 2002, Colbrunn achieved a career-high .333 batting average, along with 12 home runs and 54 RBIs. His performance that year was instrumental in helping the Diamondbacks secure a playoff berth.

In 2003, Colbrunn joined the Seattle Mariners, where he continued to be a valuable asset off the bench. His experience and steady bat provided the Mariners with a reliable option in pinch-hitting situations. Colbrunn's final season in the majors was with the Texas Rangers in 2004, after which he retired from playing professionally.

Throughout his career, Colbrunn was known for his disciplined approach at the plate and his ability to deliver in clutch situations. He finished his MLB career with a .289 batting average, 98 home runs, and 422 RBIs. After retiring as a player, Colbrunn transitioned into coaching, sharing his knowledge and experience with the next generation of players.