Frank Wren's career in Major League Baseball is best known for his roles in front office management rather than as a player. His journey in baseball management began long before he took on the role of general manager for the Atlanta Braves, a position that defined much of his career in the sport.

Wren's career in baseball management started with the Montreal Expos, where he worked in various capacities, including as an assistant general manager. His time with the Expos helped him develop a keen understanding of player evaluation and team management. This experience laid the groundwork for his future roles in MLB.

In 1999, Wren became the general manager of the Baltimore Orioles. His tenure with the Orioles was relatively short, lasting only one season. During this time, he faced challenges in team performance and management decisions, which ultimately led to his departure. Despite the brevity of his time with the Orioles, Wren gained valuable experience that would serve him well in future endeavors.

Wren's most notable role came when he joined the Atlanta Braves organization. Initially, he served as the assistant general manager under John Schuerholz, a position that allowed him to be involved in the team's strategic planning and player acquisitions. In 2007, Wren was promoted to general manager of the Braves, succeeding Schuerholz.

As the general manager of the Braves, Wren was responsible for overseeing the team's roster decisions, trades, and player development. His tenure saw a mix of successes and challenges. Wren was instrumental in acquiring key players through trades and free agency, which helped the Braves remain competitive in the National League East. Under his leadership, the Braves made several playoff appearances, although they did not advance to the World Series during his time.

Wren's approach to team building often focused on pitching, a strategy that aligned with the Braves' historical strengths. He was involved in drafting and developing young talent, which contributed to the team's depth and future potential. However, some of his decisions, particularly in free agency, were met with criticism and mixed results.

In 2014, Wren's tenure with the Braves came to an end. The team decided to part ways with him following a disappointing season. His departure marked the conclusion of a significant chapter in his career, but his influence on the Braves' roster and organizational structure was evident.

Throughout his career, Frank Wren navigated the complexities of baseball management with a focus on building competitive teams.