Drayton Florence's journey in professional football began when he was selected by the San Diego Chargers in the second round of the 2003 NFL Draft. A cornerback known for his physical style of play, Florence quickly adapted to the demands of the NFL. During his tenure with the Chargers, he developed a reputation for his ability to defend against some of the league's top receivers. His time in San Diego saw him become an integral part of the team's defensive unit, contributing to their efforts in reaching the playoffs multiple times.

After five seasons with the Chargers, Florence signed with the Jacksonville Jaguars in 2008. His stint with the Jaguars was brief, lasting only one season. Despite the short duration, he managed to make an impression with his defensive skills, recording several pass deflections and tackles. However, the following year, Florence found a new home with the Buffalo Bills, where he would spend the next three seasons.

In Buffalo, Florence became a regular starter and played a crucial role in the Bills' secondary. His tenure with the team was marked by consistent performances, including several interceptions and defensive touchdowns. Florence's ability to read the game and anticipate the quarterback's moves made him a valuable asset to the Bills' defense. His time in Buffalo was arguably one of the most stable periods of his career, as he was able to showcase his skills on a regular basis.

Following his release from the Bills in 2012, Florence signed with the Denver Broncos. However, his time with the Broncos was marred by injuries, limiting his appearances on the field. Despite this setback, he continued to pursue opportunities in the NFL, demonstrating his determination to remain in the league.

In 2013, Florence joined the Carolina Panthers, where he played for one season. During his time with the Panthers, he contributed to the team's defensive efforts, adding experience and depth to their secondary. His final season in the NFL was spent with the Detroit Lions, where he continued to provide veteran leadership and defensive prowess.

Throughout his career, Drayton Florence played for several teams, each time bringing his defensive skills and experience to the field.

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