Derek Anderson, a quarterback known for his strong arm and towering presence, began his professional football career when he was drafted by the Baltimore Ravens in the sixth round of the 2005 NFL Draft. However, his time with the Ravens was short-lived, as he was waived before the start of the regular season. The Cleveland Browns claimed him off waivers, setting the stage for the most memorable chapter of his career.

Anderson's tenure with the Browns was marked by a breakout season in 2007. After starting the season as a backup, he was thrust into the starting role in Week 2. Anderson seized the opportunity, leading the Browns to a 10-6 record, their best in years, and narrowly missing the playoffs. His performance that season included 3,787 passing yards and 29 touchdowns, earning him a Pro Bowl selection. This season stood out as the peak of his career, showcasing his ability to lead an offense and make big plays.

Despite the success of 2007, Anderson's subsequent seasons with the Browns were less consistent. Injuries and fluctuating performance led to a decline in his starting opportunities. By 2009, the Browns decided to part ways with Anderson, releasing him in March 2010.

The next chapter of Anderson's career took him to the Arizona Cardinals, where he signed a two-year contract. In Arizona, he competed for the starting quarterback position but struggled to find the same success he had in Cleveland. His time with the Cardinals was marked by a mix of starts and backup duties, and he was released after the 2010 season.

In 2011, Anderson joined the Carolina Panthers, initially as a backup to rookie quarterback Cam Newton. Over the years, Anderson proved to be a reliable backup, stepping in when needed and providing veteran leadership. His role with the Panthers was primarily as a mentor and occasional starter, filling in during Newton's injuries or when games were out of reach. Anderson's presence on the team was valued for his experience and ability to manage games effectively when called upon.

Anderson's career with the Panthers spanned several seasons, during which he re-signed multiple times, reflecting the team's trust in his abilities as a backup quarterback. His most notable performances came in relief appearances, where he demonstrated his readiness and understanding of the game.

In 2018, Anderson signed with the Buffalo Bills, reuniting with former Panthers defensive coordinator Sean McDermott, who was then the head coach of the Bills. Anderson was brought in to provide veteran guidance to the Bills' young quarterbacks, including rookie Josh Allen. He made a few appearances during the season, starting two games due to injuries in the quarterback lineup.

After the 2018 season, Anderson decided to retire from professional football.

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