David Segui's journey in Major League Baseball began when he was drafted by the Baltimore Orioles in the third round of the 1987 MLB Draft. Born on July 19, 1966, in Kansas City, Kansas, Segui was the son of former major league pitcher Diego Segui. This familial connection to the sport provided him with a unique perspective and understanding of the game from an early age.

Segui made his MLB debut with the Orioles on May 6, 1990. Primarily a first baseman, he was known for his defensive skills and switch-hitting ability. Over the course of his career, Segui played for several teams, including the New York Mets, Montreal Expos, Seattle Mariners, Toronto Blue Jays, Texas Rangers, and Cleveland Indians, in addition to his time with the Orioles.

During his tenure with the Orioles, Segui developed a reputation as a reliable player. His ability to hit for average and his solid defensive play made him a valuable asset to the teams he played for. In 1994, Segui was traded to the New York Mets, where he continued to demonstrate his consistent performance at the plate and in the field.

Segui's time with the Montreal Expos in 1995 was brief, but he managed to leave a positive impression before being traded to the Seattle Mariners. It was with the Mariners that Segui enjoyed some of his most productive years. In 1997, he posted a career-high batting average of .307, showcasing his ability to contribute offensively.

The Toronto Blue Jays acquired Segui in 1999, and he continued to perform well, maintaining a batting average above .300 during his stint with the team. His consistent performance caught the attention of the Texas Rangers, who signed him as a free agent in 2000. Segui's time with the Rangers was marked by his steady presence both on and off the field.

In 2001, Segui returned to the Orioles, where he spent the final years of his career. Despite battling injuries, he remained a respected figure in the clubhouse and provided veteran leadership to the younger players. Segui retired from professional baseball after the 2004 season, concluding a career that spanned over a decade and a half.

Throughout his career, Segui was known for his professionalism and work ethic. He finished with a career batting average of .291, 139 home runs, and 684 RBIs. While he may not have been a household name, Segui's contributions to the teams he played for were appreciated by teammates and fans alike.