Daniel Hudson's journey in Major League Baseball began when he was drafted by the Chicago White Sox in the fifth round of the 2008 MLB Draft. A right-handed pitcher, Hudson quickly ascended through the minor league ranks, making his MLB debut with the White Sox in September 2009. His initial performances showed promise, and he soon became a player to watch.

In 2010, Hudson was traded to the Arizona Diamondbacks, a move that would define a significant portion of his career. With the Diamondbacks, he found more opportunities to showcase his skills as a starting pitcher. The 2011 season was particularly noteworthy for Hudson, as he posted a 16-12 record with a 3.49 ERA, establishing himself as a reliable starter in the rotation. His performance that year helped the Diamondbacks clinch the National League West title.

However, Hudson's career faced challenges when he underwent Tommy John surgery in 2012, a procedure that sidelined him for the entire 2013 season. Despite the setback, he worked diligently on his recovery and returned to the mound in 2014, though his role had shifted. The Diamondbacks transitioned him to a relief pitcher, a position he adapted to over the following seasons.

Hudson's resilience was evident as he continued to pitch effectively out of the bullpen. In 2016, he appeared in 70 games for Arizona, demonstrating his ability to handle a significant workload. After the 2016 season, Hudson entered free agency and signed with the Pittsburgh Pirates. His tenure with the Pirates lasted one season, during which he maintained his role as a reliever.

The next chapter of Hudson's career saw him signing with the Los Angeles Dodgers in 2018. Although his time with the Dodgers was brief, it provided him with the opportunity to further refine his skills as a reliever. In 2019, Hudson joined the Toronto Blue Jays, but his stay in Toronto was short-lived as he was traded mid-season to the Washington Nationals.

Hudson's arrival in Washington proved to be a turning point. He played a crucial role in the Nationals' bullpen during their 2019 postseason run. His performance in the World Series was particularly memorable, as he recorded the final out in Game 7 against the Houston Astros, securing the Nationals' first-ever World Series championship. This moment became a highlight of Hudson's career, showcasing his ability to perform under pressure.

Following his success with the Nationals, Hudson continued to pitch for Washington through the 2020 season. In 2021, he was traded back to the San Diego Padres, a team he had briefly been with earlier in his career. Hudson's experience and veteran presence were valuable assets to the Padres' bullpen as they competed in a highly competitive National League West division.

Throughout his career, Daniel Hudson demonstrated adaptability and perseverance.