Dan Driessen's journey in Major League Baseball began when he debuted with the Cincinnati Reds in 1973. Known for his left-handed batting and solid defensive skills, Driessen quickly became an integral part of the Reds' lineup. His versatility allowed him to play both first and third base, although he spent the majority of his career at first.

In 1976, Driessen played a crucial role in the Reds' World Series victory. During the series, he became the first National League player to serve as a designated hitter in a World Series game, a role that had just been introduced to the league. His performance helped the Reds secure their second consecutive championship, cementing their place as one of the dominant teams of the era.

Throughout the late 1970s and early 1980s, Driessen remained a consistent presence in the Reds' lineup. He was known for his ability to get on base and his knack for driving in runs. In 1977, he had one of his best seasons, hitting .300 with 17 home runs and 91 RBIs. His offensive contributions were complemented by his reliable defense at first base.

Driessen's tenure with the Reds lasted until 1984, when he was traded to the Montreal Expos. His time with the Expos was brief, as he was soon traded to the San Francisco Giants. With the Giants, Driessen continued to demonstrate his batting skills, providing veteran leadership to a young team.

In 1986, Driessen signed with the Houston Astros, where he played a supporting role. His experience and steady performance were valuable assets to the team. The following year, he joined the St. Louis Cardinals, marking the final stop in his major league career. Driessen retired after the 1987 season, leaving behind a legacy of consistent performance and adaptability.