Chris Bosio's journey in Major League Baseball began when he was drafted by the Milwaukee Brewers in the second round of the 1982 MLB Draft. A right-handed pitcher, Bosio made his debut with the Brewers on August 3, 1986. Over the next several years, he established himself as a reliable starter in the Brewers' rotation.

During his tenure with Milwaukee, Bosio developed a reputation for his control and ability to pitch deep into games. In 1989, he had one of his best seasons, posting a 15-10 record with a 2.95 ERA, which ranked among the best in the American League that year. His performance helped the Brewers remain competitive in the league, and he became a mainstay in their pitching lineup.

Bosio's time with the Brewers came to an end after the 1992 season when he signed as a free agent with the Seattle Mariners. His move to Seattle marked a new chapter in his career, and he quickly became an integral part of the Mariners' pitching staff. In Seattle, Bosio continued to demonstrate his skills on the mound, and he achieved a career highlight on April 22, 1993, when he pitched a no-hitter against the Boston Red Sox. This remarkable feat was the second no-hitter in Mariners' history and solidified Bosio's place in the team's lore.

Throughout his career with the Mariners, Bosio was known for his competitive spirit and ability to perform under pressure. He played a crucial role in helping the Mariners reach the postseason for the first time in franchise history in 1995. During the American League Division Series against the New York Yankees, Bosio's performance in Game 2 was instrumental in keeping the Mariners' playoff hopes alive, as he pitched effectively to secure a victory.

Bosio's career, however, was not without its challenges. Injuries began to take a toll on his performance, and after the 1996 season, he decided to retire from professional baseball. Over his career, Bosio compiled a record of 94 wins and 93 losses, with an ERA of 3.96 and 1,059 strikeouts.

After retiring as a player, Bosio transitioned into coaching, where he continued to share his knowledge and experience with younger players.