Brian Williams, a right-handed pitcher, embarked on his Major League Baseball journey when he was drafted by the Houston Astros in the first round of the 1990 MLB Draft. His professional debut came on April 25, 1991, with the Astros, marking the beginning of a career that spanned nearly a decade in the major leagues.

Williams spent the early years of his career with the Houston Astros, where he showcased his skills on the mound. During his tenure with the Astros, he was primarily utilized as a starting pitcher. His rookie season in 1991 saw him make 14 starts, and he continued to be a part of the Astros' rotation in the following years. Williams' time with Houston was marked by steady performances, although he faced challenges typical of young pitchers adjusting to the major leagues.

In 1994, Williams was traded to the San Diego Padres, where he continued to develop his pitching repertoire. His stint with the Padres was relatively short, and he soon found himself on the move again. The following year, he joined the Detroit Tigers, where he spent parts of two seasons. With the Tigers, Williams transitioned between starting and relieving, adapting to the needs of the team.

The latter half of Williams' career saw him don several different uniforms. In 1996, he was traded to the Baltimore Orioles, where he contributed as a reliever. His role in the bullpen allowed him to refine his skills in high-pressure situations, a valuable asset for any team. Williams' adaptability was further tested when he joined the Cincinnati Reds in 1997, continuing his role as a relief pitcher.

Williams' journey through the major leagues also included a brief period with the Cleveland Indians in 1998. His time with the Indians was short-lived, and he soon returned to the Astros, the team where his career began. This second stint with Houston saw him once again take on a relief role, providing depth and experience to the pitching staff.

In 1999, Williams signed with the Chicago Cubs, adding another chapter to his diverse career. His experience and knowledge of the game were assets to the Cubs' bullpen. However, his time with the Cubs was brief, and he soon found himself with the New York Yankees. Although his tenure with the Yankees was short, it was a testament to his ability to remain in demand across the league.

Throughout his career, Williams was known for his ability to adapt to various roles on the pitching staff. Whether as a starter or reliever, he brought a level of professionalism and consistency to the teams he played for. His career statistics reflect the journeyman nature of his time in the majors, with appearances for multiple teams and contributions in different capacities.

Brian Williams' career in Major League Baseball concluded in 2000.