Brian Boehringer's journey through Major League Baseball began when he was drafted by the Houston Astros in the 1990 MLB Draft. However, it wasn't until he was traded to the New York Yankees that he made his major league debut. Boehringer, a right-handed pitcher, first appeared on the mound for the Yankees in 1995. His role primarily involved pitching in relief, although he occasionally started games when needed.

During his time with the Yankees, Boehringer was part of the team that won the World Series in 1996. His contributions during the postseason were valuable, as he pitched in several games, helping the Yankees secure their championship. After his stint with the Yankees, Boehringer was traded to the San Diego Padres in 1997. With the Padres, he continued to serve as a reliable bullpen option, and in 1998, he once again found himself on a team that reached the World Series. Although the Padres did not win the championship, Boehringer's presence in the bullpen was a steadying factor throughout the season.

In 2001, Boehringer signed with the San Francisco Giants, where he continued to pitch in relief. His tenure with the Giants was relatively short, and he soon found himself with the Pittsburgh Pirates. Boehringer spent several seasons with the Pirates, where he was utilized in various pitching roles, including as a starter on occasion. His ability to adapt to different pitching situations made him a valuable asset to the Pirates' pitching staff.

Boehringer's career in the major leagues concluded with the Minnesota Twins in 2004. Throughout his time in MLB, he was known for his work ethic and ability to perform under pressure.