Brendan Harris, a professional baseball infielder, began his Major League Baseball (MLB) career with the Chicago Cubs. Drafted in the fifth round of the 2001 MLB Draft, Harris made his debut on July 6, 2004, with the Cubs. His time with the team was brief, as he was traded to the Montreal Expos later that year. This move marked the beginning of a journey through several teams in the league.

With the Expos, who became the Washington Nationals in 2005, Harris found opportunities to showcase his skills. However, his tenure with the Nationals was short-lived, and he was traded to the Cincinnati Reds in 2006. His stint with the Reds was also brief, as he was traded to the Tampa Bay Devil Rays later that year. It was with the Devil Rays that Harris began to see more consistent playing time, appearing in 117 games during the 2007 season. That year, he posted a .286 batting average, hit 12 home runs, and drove in 59 runs, demonstrating his ability to contribute offensively.

In November 2007, Harris was traded to the Minnesota Twins, where he spent the next three seasons. During his time with the Twins, Harris played various infield positions, including shortstop, second base, and third base. His most productive season with the Twins came in 2008, when he played in 129 games, hit .265, and recorded 7 home runs and 49 RBIs. Harris's versatility in the infield provided the Twins with valuable depth, and he was part of the team's postseason roster in 2009.

After his tenure with the Twins, Harris was traded to the Baltimore Orioles in December 2010. However, he did not play a game for the Orioles, as he was released before the start of the 2011 season. He then signed a minor league contract with the Colorado Rockies but did not make it back to the major leagues with them. In 2012, Harris signed with the Los Angeles Angels of Anaheim, where he spent the season in their minor league system.

Harris returned to the majors in 2013 with the Angels, appearing in 44 games. During this time, he batted .206 with 4 home runs and 9 RBIs. Following the 2013 season, Harris signed a minor league contract with the New York Yankees but was released before the start of the 2014 season. He subsequently retired from professional baseball.