Bill Gullickson's journey through Major League Baseball began when he was selected as the second overall pick in the 1977 MLB Draft by the Montreal Expos. A right-handed pitcher, Gullickson quickly rose through the ranks, making his major league debut with the Expos in 1979. His rookie season set the stage for a career that would span over a decade and a half, during which he played for several teams and left a lasting impression on the game.

In 1980, Gullickson's first full season in the majors, he showcased his potential by posting a 10-5 record with a 3.00 ERA. His standout performance came on September 10, 1980, when he struck out 18 batters in a game against the Chicago Cubs, setting a then-record for the most strikeouts in a single game by a rookie. This achievement highlighted his ability to dominate on the mound and placed him in the spotlight as one of the promising young pitchers of his time.

Gullickson continued to be a reliable starter for the Expos throughout the early 1980s. In 1983, he achieved a career-high 17 wins, finishing the season with a 17-12 record and a 3.24 ERA. His consistency and durability were key assets for the Expos' pitching rotation, and he remained a mainstay in their lineup until 1985.

In 1986, Gullickson was traded to the Cincinnati Reds, where he continued to perform well, recording a 15-12 record with a 3.38 ERA. His tenure with the Reds was brief, as he was traded to the New York Yankees in 1987. During his time with the Yankees, Gullickson struggled to find his rhythm, finishing the season with a 4-2 record and a 4.88 ERA.

Seeking a fresh start, Gullickson took an unconventional step in his career by signing with the Yomiuri Giants of Japan's Nippon Professional Baseball (NPB) for the 1988 season. His decision to play in Japan was a rare move for American players at the time, but it proved to be a fruitful experience. Gullickson excelled in the Japanese league, posting a 21-8 record with a 2.55 ERA and helping the Giants win the Central League pennant.

After two successful seasons in Japan, Gullickson returned to Major League Baseball in 1990, signing with the Houston Astros. He enjoyed a solid comeback season, finishing with a 10-14 record and a 3.95 ERA. The following year, he joined the Detroit Tigers, where he experienced a resurgence in his career. In 1991, Gullickson led the American League with 20 wins, becoming the first Tigers pitcher to reach that milestone since 1984. His performance earned him the American League Comeback Player of the Year award.

Gullickson remained with the Tigers until 1994, providing veteran leadership and stability to their pitching staff. Over his career, he amassed a total of 162 wins, a 3.93 ERA, and 1,279 strikeouts. Known for his control and ability to pitch deep into games, Gullickson was a dependable starter who could be counted on to deliver quality innings.

Off the field, Gullickson was known for managing Type 1 diabetes, a condition he was diagnosed with at the age of 15. His ability to maintain a successful career while managing his health was an inspiration to many and demonstrated his perseverance and determination.