Andy Van Slyke's journey through Major League Baseball began when he was drafted by the St. Louis Cardinals as the sixth overall pick in the 1979 MLB Draft. Known for his athleticism and defensive prowess, Van Slyke quickly rose through the ranks of the Cardinals' farm system. By 1983, he made his MLB debut with the Cardinals, showcasing his skills as an outfielder and occasional first baseman.

During his tenure with the Cardinals, Van Slyke demonstrated his ability to contribute both offensively and defensively. He played a key role in the Cardinals' success during the mid-1980s, including their National League pennant-winning season in 1985. His versatility allowed him to play multiple positions, although he primarily excelled in the outfield. Despite his contributions, Van Slyke's time with the Cardinals came to an end in 1986 when he was traded to the Pittsburgh Pirates.

The trade to the Pirates marked a new chapter in Van Slyke's career. In Pittsburgh, he found a home in center field and became an integral part of the team's lineup. Van Slyke's tenure with the Pirates was marked by several standout seasons, particularly from 1988 to 1992. During this period, he was selected to three All-Star teams and won five Gold Glove Awards, underscoring his reputation as one of the best defensive outfielders in the league.

Van Slyke's offensive numbers also flourished with the Pirates. He consistently posted solid batting averages and was known for his ability to drive in runs. His best season came in 1992 when he finished fourth in the National League MVP voting, thanks to a .324 batting average, 14 home runs, and 89 RBIs. That year, the Pirates reached the National League Championship Series, although they fell short of advancing to the World Series.

After his successful run with the Pirates, Van Slyke's career began to wind down. He spent the 1995 season with the Baltimore Orioles and the Philadelphia Phillies, but injuries and age had started to take their toll. Van Slyke retired from professional baseball following the 1995 season, leaving behind a legacy as a talented outfielder with a strong arm and a reliable bat.

Throughout his career, Van Slyke was known for his charismatic personality and leadership on and off the field.