Andy Green's journey in professional baseball began when he was drafted by the Arizona Diamondbacks in the 24th round of the 2000 MLB Draft. A native of Lexington, Kentucky, Green played college baseball at the University of Kentucky, where he honed his skills as an infielder. His perseverance and hard work paid off when he made his Major League debut with the Diamondbacks on June 12, 2004.

During his time with the Diamondbacks, Green played primarily as a utility infielder. His versatility allowed him to fill various roles on the team, playing second base, third base, and shortstop. In the 2005 season, Green saw his most extensive action in the majors, appearing in 76 games. That year, he posted a batting average of .239 with two home runs and 12 RBIs. Despite these modest numbers, Green's ability to adapt to different positions made him a valuable asset to the team.

After his stint with the Diamondbacks, Green spent some time in the minor leagues and also played internationally. In 2007, he signed with the Nippon Ham Fighters of Japan's Nippon Professional Baseball (NPB). His experience in Japan added a new dimension to his career, as he gained exposure to a different style of play and further developed his skills.

Green returned to the United States and continued to play in the minor leagues, including time with the New York Mets and Cincinnati Reds organizations. His playing career concluded after the 2009 season, but his involvement in baseball was far from over.

Transitioning from player to coach, Green began his coaching career in the Diamondbacks organization. He served as a manager in the minor leagues, where he demonstrated a keen understanding of the game and an ability to develop young talent. His managerial skills did not go unnoticed, and in 2015, he was hired as the third base coach for the Arizona Diamondbacks.

In October 2015, Green's coaching career took a significant step forward when he was named the manager of the San Diego Padres. At 38 years old, he became one of the youngest managers in Major League Baseball at the time. Green's tenure with the Padres lasted until September 2019. During his time as manager, he focused on developing a young roster and instilling a competitive spirit within the team. Although the Padres did not achieve a winning record under his leadership, Green's efforts in player development laid the groundwork for the team's future success.

After his managerial stint with the Padres, Green continued his coaching career by joining the Chicago Cubs as a bench coach in 2020. In this role, he worked alongside manager David Ross, contributing his experience and knowledge to the team's strategic planning and in-game decision-making.