Andrew Romine's journey in Major League Baseball is characterized by his adaptability and utility on the field. Born on December 24, 1985, in Winter Haven, Florida, Romine grew up in a baseball family. His father, Kevin Romine, played in the majors, and his brother, Austin Romine, also pursued a career in professional baseball. Andrew attended Arizona State University, where he played college baseball for the Sun Devils, honing his skills and preparing for a future in the sport.

Romine was selected by the Los Angeles Angels of Anaheim in the fifth round of the 2007 MLB Draft. He made his major league debut with the Angels on September 24, 2010. During his time with the Angels, Romine was primarily utilized as a backup infielder, providing depth across multiple positions. His ability to play various infield spots made him a valuable asset for the team, although he did not see extensive playing time.

In March 2014, Romine was traded to the Detroit Tigers, where he spent the majority of his career. With the Tigers, he continued to be a utility player, capable of filling in at shortstop, second base, third base, and occasionally in the outfield. His defensive flexibility allowed the Tigers to use him in a variety of situations, often as a late-inning replacement or spot starter. One of the highlights of his tenure with the Tigers came on September 30, 2017, when Romine played all nine positions in a single game against the Minnesota Twins, becoming just the fifth player in MLB history to achieve this feat.

After his time with the Tigers, Romine signed with the Seattle Mariners in 2018. His role with the Mariners was similar to his previous teams, providing depth and experience off the bench. In 2019, he joined the Philadelphia Phillies organization but did not appear in a major league game for them. Instead, he spent the season with their Triple-A affiliate, the Lehigh Valley IronPigs.

Romine returned to the majors in 2020 with the Texas Rangers, where he continued to serve as a utility infielder. The following year, he signed a minor league contract with the Chicago Cubs and was called up to the majors during the 2021 season. With the Cubs, Romine once again demonstrated his ability to play multiple positions, contributing wherever needed.

Throughout his career, Romine was known for his defensive skills and versatility.